Abstract

Parasitic nematodes have long harmed crops, pets, livestock, and humans. Wide usage of current broad-spectrum anthelmintics as preventive medicine has led to emerging nematode resistance against these compounds in many human populations, prompting the exploration of compounds with novel genetic targets. Our discovery that an insect pheromone can act both as an attractant as well as an anthelmintic represents a unique opportunity to define a novel drug target. Our proposal is to identify the mode-of-action for this pheromone using a lipid- binding protein as the genetic entry point. We propose three independent strategies involving candidate gene expression and functional analysis, along with forward genetic screens to identify the pheromone receptor and other components of the signaling pathway.

Public Health Relevance

New compounds are needed to treat parasitic nematode infections. We have discovered an insect pheromone that can paralyze and severely retard the development of an insect-associated nematode. Our proposal will investigate the mode-of-action for this potential anthelmintic and may lead to potential treatments against human filarial nematodes or other economically important nematode parasites.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Continuance Award (SC3)
Project #
2SC3GM105579-05
Application #
9280379
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Krasnova, Irina N
Project Start
2013-07-01
Project End
2021-07-31
Budget Start
2017-09-01
Budget End
2018-07-31
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
California State University Northridge
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
055752331
City
Northridge
State
CA
Country
United States
Zip Code
91330

  Publications

de la Guardia, Carolina; Stephens, David E; Dang, Hang T et al. (2018) Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2. Molecules 23:
Nguyen, Vu T; Dang, Hang T; Pham, Hoang H et al. (2018) Highly Regio- and Stereoselective Catalytic Synthesis of Conjugated Dienes and Polyenes. J Am Chem Soc 140:8434-8438
Doens, Deborah; Valiente, Pedro A; Mfuh, Adelphe M et al. (2017) Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease. ACS Chem Neurosci 8:1232-1241
Mfuh, Adelphe M; Schneider, Brett D; Cruces, Westley et al. (2017) Metal- and additive-free photoinduced borylation of haloarenes. Nat Protoc 12:604-610
Jans, Petra E; Mfuh, Adelphe M; Arman, Hadi D et al. (2017) Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues. J Nat Prod 80:676-683
Lakey-Beitia, Johant; González, Yisett; Doens, Deborah et al. (2017) Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-? Aggregation in Alzheimer's Disease. J Alzheimers Dis 60:S59-S68
Jin, Shengfei; Nguyen, Vu T; Dang, Hang T et al. (2017) Photoinduced Carboborative Ring Contraction Enables Regio- and Stereoselective Synthesis of Multiply Substituted Five-Membered Carbocycles and Heterocycles. J Am Chem Soc 139:11365-11368
Renahan, Tess; Hong, Ray L (2017) A species-specific nematocide that results in terminal embryogenesis. J Exp Biol 220:3238-3247
Koneru, Sneha L; Salinas, Heilly; Flores, Gilberto E et al. (2016) The bacterial community of entomophilic nematodes and host beetles. Mol Ecol 25:2312-24
Mfuh, Adelphe M; Nguyen, Vu T; Chhetri, Bhuwan et al. (2016) Additive- and Metal-Free, Predictably 1,2- and 1,3-Regioselective, Photoinduced Dual C-H/C-X Borylation of Haloarenes. J Am Chem Soc 138:8408-11

Showing the most recent 10 out of 19 publications