The primary objective of this proposal is to continue our aging-related research training efforts on both the University of Colorado Anschutz Medical Campus (UC-AMC) and the University of Colorado-Boulder Campus (UC-B). The focus of this second renewal of our 5-year training grant will be expanded to reflect the new title Integrative Physiology of Aging. As with the past 2 funding cycles, the major participating programs will be the Division of Geriatric Medicine (DGM) and the Center for Human Nutrition (CHN) at UC-AMC, and the Department of Integrative Physiology (IPHY) at UC-B. However, the expanded focus will enable us to involve additional outstanding aging-related investigators from our 2 campuses as additional mentors on this T32. Of the 52 training grants at the University of Colorado, this is the only one specifically dedicated to aging issues. Because of our success during our last 9 years of funding and our expectations for wider faculty participation, we are now requesting support for 5 pre- and 5 post-doctoral trainees each year. The specific objectives of this training program are to: 1) expand the cohort of faculty mentors interested in aging research; 2) recruit and retain outstanding pre- (Ph.D.) and post-doctoral (Ph.D. and M.D.) trainees; 3) support their research training through a combination of experiential and didactic instruction; 4) insure the highest level of academic success through the conscientious monitoring of a carefully constructed career development plan; 5) enhance the mentoring skills of a cadre of associate mentors through co-mentoring with a more experienced primary mentor. These objective will be carried out by offering: 1) up to 2 years of research training support (the second years dependent upon successful progress); 2) dual mentoring by outstanding primary and associate mentors; 3) a wide variety of relevant classroom experiences on both campuses; 4) frequent and careful review of trainee progress/success; 5) ongoing appraisal of the program goals, strength and weaknesses; and 6) sound financial and administrative oversight. Our previous success is exemplified by our ability to: 1) fill our positions with outstanding trainees; 2) produe academically successful and productive trainees; 3) build a pipeline of mentors, and transition trainees to associate mentors and associate mentors to primary mentors; and 4) expand aging-research at both campuses through ongoing collaboration among the participating programs and faculty.
The overall objective of this University of Colorado NRSA is to attract and mentor outstanding pre- (Ph.D.) and postdoctoral (Ph.D. and M.D.) trainees in the 'Integrative Physiology of Aging'. These trainees will be equipped with the skills to become successful, independent academic leaders in the field of aging research.
|Myers, Casey A; Laz, Peter J; Shelburne, Kevin B et al. (2018) The impact of hip implant alignment on muscle and joint loading during dynamic activities. Clin Biomech (Bristol, Avon) 53:93-100|
|Martens, Christopher R; Denman, Blair A; Mazzo, Melissa R et al. (2018) Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 9:1286|
|Heveran, Chelsea M; Rauff, Adam; King, Karen B et al. (2018) A new open-source tool for measuring 3D osteocyte lacunar geometries from confocal laser scanning microscopy reveals age-related changes to lacunar size and shape in cortical mouse bone. Bone 110:115-127|
|Abbate, Lauren M; Jeffreys, Amy S; Coffman, Cynthia J et al. (2018) Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. Arthritis Care Res (Hoboken) 70:1141-1149|
|Bade, Michael; Struessel, Tamara; Paxton, Roger et al. (2018) Performance on a Clinical Quadriceps Activation Battery Is Related to a Laboratory Measure of Activation and Recovery After Total Knee Arthroplasty. Arch Phys Med Rehabil 99:99-106|
|Capin, Jacob J; Khandha, Ashutosh; Zarzycki, Ryan et al. (2018) Gait Mechanics After ACL Reconstruction Differ According to Medial Meniscal Treatment. J Bone Joint Surg Am 100:1209-1216|
|Rossman, Matthew J; Santos-Parker, Jessica R; Steward, Chelsea A C et al. (2018) Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults. Hypertension 71:1056-1063|
|Paxton, Roger J; Forster, Jeri E; Miller, Matthew J et al. (2018) A Feasibility Study for Improved Physical Activity After Total Knee Arthroplasty. J Aging Phys Act 26:7-13|
|Gavin, Kathleen M; Shea, Karen L; Gibbons, Ellie et al. (2018) Gonadotropin-releasing hormone agonist in premenopausal women does not alter hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone. Am J Physiol Endocrinol Metab 315:E316-E325|
|Boule, Lisbeth A; Ju, Cynthia; Agudelo, Marisela et al. (2018) Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 66:35-43|
Showing the most recent 10 out of 133 publications