This proposal is to renew support for a Postdoctoral Research Training Program in Microbial Pathogenesis of Infectious Diseases. Highly successful in its first 20 years, this program has been extensively redesigned to prepare graduates to meet growing workforce needs in translational science. This program has been structured to synergize with an innovative program established for pre-doctoral students at Tufts University with support from the Howard Hughes Medical Institute (MERGE-ID). Both programs utilize a combination of required co- mentorship by a clinical researcher and a basic laboratory scientist as well as coursework and conferences specifically designed to blend a basic science orientation with medically oriented clinical research and to encourage interaction between ID clinicians and basic scientists. This program is designed to train both M.D. fellows in Infectious Diseases as well as Ph.D. fellows interested in studying microbial pathogenesis. Ph.D. trainees take a specially designed course in Medical Problem based Learning that teaches self-learning using cases from the 1st year medical school curriculum. In addition, they participate in outpatient clinics in Infectious diseases to directly observe medical care of specific diseases. M.D. trainees must take graduate level courses in Host-pathogen interactions alongside Ph.D. students in the MERGE-ID program. Although changes have been made to the structure and curriculum, the core of this program remains its outstanding faculty who share an interest in Infectious Diseases. Strengths of the faculty include investigations of: 1) virulence determinants in bacterial, viral, parasitic and fungal pathogens;2) infections in immunocompromised hosts;3). Interactions of the host immune system with bacterial, viral and fungal pathogens;3) interspecies microbial interactions and the impact on infectious disease pathogenesis;4) clinical study design. The 26 faculty are highly interactive and have a long history of collaboration as evidenced by a large number of shared publications and grants. Another major strength of the program has been the use of Personal Progress Review Committees comprised of 4 faculty members that meet every 6 months to ensure progress of the trainee. This format has allowed the program to achieve a high success rate (>75%) for its trainees in remaining in academic, industrial, or governmental research despite the fact that historically, the majority of the in trainees that have entered the program are M.D. fellows with no prior research experience. The success of the program has translated into continued highly successful recruitment, including among underrepresented minorities that comprised greater than 25% of the trainees during the most recent period. The application requests support for 4post-doctoral trainees per year. Trainees are chosen through a rigorous selection process and are supported for 2-3 years.
The goal of this proposal is to train M.D. and Ph.D. post-doctoral fellows in the study of medically oriented research in Infectious diseases. Trainees in our program will graduate with an extensive knowledge of clinical infectious diseases as well as skill in basic laboratory and clinical research techniques needed for a successful career as an Infectious Disease researcher. Programs to ensure a pipeline of young scientists with an understanding of the clinical implications of their research and the ability to translate laborator discoveries into processes that directly impact human health are greatly needed in this country.
|Severin, Geoffrey B; Ramliden, Miriam S; Hawver, Lisa A et al. (2018) Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae. Proc Natl Acad Sci U S A 115:E6048-E6055|
|Reyes-Robles, Tamara; Dillard, Rebecca S; Cairns, Lynne S et al. (2018) Vibrio cholerae outer membrane vesicles inhibit bacteriophage infection. J Bacteriol :|
|Boot, Maikel; Commandeur, Susanna; Subudhi, Amit K et al. (2018) Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action. Antimicrob Agents Chemother 62:|
|Klein, Brian A; Cornacchione, Louis P; Collins, Marisha et al. (2017) Using Tn-seq To Identify Pigmentation-Related Genes of Porphyromonas gingivalis: Characterization of the Role of a Putative Glycosyltransferase. J Bacteriol 199:|
|Hawver, Lisa A; Giulietti, Jennifer M; Baleja, James D et al. (2016) Quorum Sensing Coordinates Cooperative Expression of Pyruvate Metabolism Genes To Maintain a Sustainable Environment for Population Stability. MBio 7:|
|Alraddadi, Basem; Nierenberg, Natalie E; Price, Lori Lyn et al. (2016) Characteristics and outcomes of neutropenia after orthotopic liver transplantation. Liver Transpl 22:217-25|
|Pacek, Lauren R; Vandrey, Ryan; Dermody, Sarah S et al. (2016) Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use. Drug Alcohol Depend 167:228-32|
|Bialas, Kristy M; Westreich, Daniel; Cisneros de la Rosa, Eduardo et al. (2016) Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants. J Infect Dis 214:1916-1923|
|Collinet-Adler, Stefan; Babji, Sudhir; Francis, Mark et al. (2015) Environmental Factors Associated with High Fly Densities and Diarrhea in Vellore, India. Appl Environ Microbiol 81:6053-8|
|Isaac, Dervla T; Laguna, Rita K; Valtz, Nicole et al. (2015) MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth. Proc Natl Acad Sci U S A 112:E5208-17|
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