The overall goal of this program is to train both M.D.'s and Ph.D. postdoctoral fellows for academic careers in pediatric immunology. In the original period of funding, there were 12 applicants for these spots, and seven were admitted during the years 1990 to 1994. Of these individuals, five have been M.D.'s, and two have been Ph.D's. Three of the five trainees have now achieved additional NIH funding, and all of those who have left have remained in research positions. Since this training program was initiated, a teaching program in immunology was established, bringing together the graduate teaching faculty (Ph.D.'s andM.D.'s) to strengthen the teaching interactions between the NJC, UCHSC, and the Diabetes Center. In addition, there has been the creation of an independent Department of Immunology under an interim chair, Dr. Katie Haskins. This training program is separate from the Allergy/Immunology Fellowship Program, a two year program that enrolls M.D.'s with more clinic responsibilities than is expected of fellows in the training program. For fellows in the three year training program, there are peer interactions with Ph.D.'s and specific training opportunities with career immunologists. Following a maximum of two six-week rotations, trainees select a supervisor, in whose laboratory they will work the remaining of the three year period. The trainer submits a plan to the training committee of proposed work within six months of joining the laboratory, and, if acceptable, this plan is approved. Trainees become familiar with bench work in more than one area, including molecular biology, cell biology, and/or animal experimentation as appropriate to the project chosen. The program has been somewhat more successful in attracting M.D.'s, partially because there was top priority to applicants with M.D. degrees. The trainee may require or recommend optional course work, depending upon the prior experience of the trainee. It is anticipated that M.D.'s without Ph.D.'s will require additional training in basic immunology and molecular biology. In addition to course work, seminars, journal clubs and research in progress meetings are held at regular intervals. There are correlated seminars in autoimmunity, immunopathology, immunodeficiency, immunity to an infectious agent, and transplantation immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007365-09
Application #
2671536
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1990-09-01
Project End
2000-08-31
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206
Dreyfus, David H; Liu, Yang; Ghoda, Lucy Y et al. (2011) Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-*B and p53. Virol J 8:422
Dreyfus, David H (2009) Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity. PLoS ONE 4:e5778
Howell, Michael D; Wollenberg, Andreas; Gallo, Richard L et al. (2006) Cathelicidin deficiency predisposes to eczema herpeticum. J Allergy Clin Immunol 117:836-41
Howell, Michael D; Gallo, Richard L; Boguniewicz, Mark et al. (2006) Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24:341-8
Howell, Michael D; Boguniewicz, Mark; Pastore, Saveria et al. (2006) Mechanism of HBD-3 deficiency in atopic dermatitis. Clin Immunol 121:332-8
Howell, Michael D; Novak, Natalija; Bieber, Thomas et al. (2005) Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. J Invest Dermatol 125:738-45
Goleva, Elena; Cardona, Ivan D; Ou, Liang-Shiou et al. (2005) Factors that regulate naturally occurring T regulatory cell-mediated suppression. J Allergy Clin Immunol 116:1094-100
Liu, Edwin; Moriyama, Hiroaki; Paronen, Johanna et al. (2003) Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse. J Autoimmun 21:213-9
Nomura, Ichiro; Goleva, Elena; Howell, Michael D et al. (2003) Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171:3262-9
Liu, Edwin; Bao, Fei; Barriga, Katherine et al. (2003) Fluctuating transglutaminase autoantibodies are related to histologic features of celiac disease. Clin Gastroenterol Hepatol 1:356-62

Showing the most recent 10 out of 24 publications