The Mayo Clinic Immunology Ph.D.Training Program seeks to train leaders for the next generation of immunologists. This training grant proposal requests support for 6 Ph.D. students who will be trained in productive biomedical research programs supporting a premier academic not-for-profit medical institution. The highly productive training faculty provides a rich training environment of basic and clinical investigators combining studies of fundamental immunology with the translational potential of the discipline. The training program has an exemplary track record in preparing students to succeed in scientific careers. Of 38 students supported by this training grant, 28 have graduated with the Ph.D. (9 still in the program), and 18 (82%) of the 22 who have now have finished postdoctoral training having advanced to academic appointments. The other 4 are employed in the private sector. Seven (18%) of the 38 trainees are designated URM with 4 out of 5 finished with their training in academic positions and one in industry. There are currently 18 training grant eligible students in the program. Students in the Program receive advanced training in primary literature focused coursework and electives offered in a multidisciplinary setting. Milestones in the Program place emphasis on each trainee's mastering the skills needed to formulate critical questions, devise experimental strategies to provide definitive insights into the questions being addressed. Students learn to communicate ideas and research findings effectively using oral and written formats and practice these skills in classroom settings, in grantsmanship courses, at national and international scientific meetings, and by publishing original research articles in mainline scientific journals. The typical training period is 5.4 years, capped by mentoring on the next phases of their developing careers.

Public Health Relevance

This training grant supports six predoctoral trainees in the Immunology Training Program of Mayo Graduate School, providing students with the requisite research and leadership skills to become heads of research laboratories and leaders in the biomedical sciences. The program has an outstanding track record with 97% of trainees supported by this grant earning the Ph.D. or progressing toward their degrees and of all the graduates who have finished their training having attained faculty positions (82%) or positions in the private sector (18%). Understanding how the immune system functions and its role in disease pathogenesis is critical to developing innovative approaches to patients care. The intersection of the science of immunology with the goals of academia, medical practice, and the private pharmaceutical sector provides opportunity for our graduates and a mandate to train more scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007425-24
Application #
9730333
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1995-07-01
Project End
2021-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
24
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Scheid, Adam D; Van Keulen, Virginia P; Felts, Sara J et al. (2018) Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation. J Immunol 200:1917-1928
Dolence, Joseph J; Kobayashi, Takao; Iijima, Koji et al. (2018) Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice. J Allergy Clin Immunol 142:1144-1158.e8
Perez, Kimberly; Patel, Robin (2018) Survival of Staphylococcus epidermidis in Fibroblasts and Osteoblasts. Infect Immun :
Burrack, Kristina S; Huggins, Matthew A; Taras, Emily et al. (2018) Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells. Immunity 48:760-772.e4
Malo, Courtney S; Huggins, Matthew A; Goddery, Emma N et al. (2018) Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses. Nat Commun 9:633
Brown, Emily A; Lautz, Jonathan D; Davis, Tessa R et al. (2018) Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models. Mol Autism 9:48
Huseby Kelcher, April M; Atanga, Pascal A; Gamez, Jeffrey D et al. (2017) Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2Db class I molecule. FASEB J 31:2267-2275
Kremer, Kimberly N; Dinkel, Brittney A; Sterner, Rosalie M et al. (2017) TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL. Blood 130:982-994
Perez, Kimberly; Patel, Robin (2017) Staphylococcusepidermidis Small-Colony Variants Are Induced by Low pH and Their Frequency Reduced by Lysosomal Alkalinization. J Infect Dis 215:488-490
Uchida, M; Anderson, E L; Squillace, D L et al. (2017) Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium. Allergy 72:1521-1531

Showing the most recent 10 out of 34 publications