EXCEED THE SPACE PROVIDED. This proposal is a request for continued funding of an institutional pre- and postdoctoral NRSA Training Program in Immunology and Molecular pathogenesis at Northwestern University Medical School, which is in its fifth year. The predoctoral training program will be run in conjunction with the Immunology and Molecular Pathogenesis graduate track, a component of the highly successful Integrated Graduate Program in the Life Sciences (IGP). The IGP will be the mechanism for recruitment of a pool of highly qualified graduate students from which predoctoral candidates will be selected. The training program will also be supported by the NorthwesternInterdepartmental Immunobiology Center. The training program will stress the interactive nature of immunology and molecular pathogenesis, two traditionally related disciplines. Successful research in immunology and molecular pathogenesis requires consultation and collaboration among colleagues, therefore this program includes 24 trainers with primary appointments in both basic science (Microbiology-Immunology and Pathology) and clinical departments (Medicine and Surgery) at the Medical School Campus who collectively hold >10.5 million dollars per year in research funding. The training program therefore has the effect of bringing together a cadre of highly productive, well-funded researchers experienced in pre- and postdoctoral training, who can impart both basic and clinical perspectivesto a group of outstanding pre- and post-doctoral trainees. The result will be a more productive researchenvironment, both for the pre- and postdoctoral students and for the many research projects funded by grants from the NIH and other federal and private agencies. The training grant also proposes to foster trainee interactions with scientists at other institutions through trainee travel to national meetings (to present and receive critiques on their researchand to develop contacts with other scientists) and through visits of prominent scientists to Northwestern Medical School as trainee-invited speakers. The training program also serves to focus the activities at the University aimed at educating students in the ethics of science and at recruiting women and minorities to graduate and post-graduate studies in immunology and molecular pathogenesis. The program requests maintaining the current fourpredoctoral slots and expanding the postdoctoral slots from two to three per year consistent with the success of the program during the initial funding period and with an institutional commitment to double the research enterprise over the next 5-10 years. Predoctoral students will be appointed for a 2-3 year period at the end of the second year of graduate studies after they have completed their coursework and qualifying exams and have identified a researchadvisor, while postdoctoral candidates will be apjppjntecjjat the outset of their training for a_y year period while they attempt to secure independent funding. The proposed program will give trainingin immunology and molecular pathogenesis at Northwestern the continued constancy required to maintain the momentum gained during the previous funding period and will allow the continued supply of highly trained young investigators with primary interests in the basic mechanisms of host-parasite interactions governing disease processes. PERSONNEL ENGAGED ON PROJECT, INCLUDING CONSULTANTS/COLLABORATORS. Use continuation pages as needed to provide the required information in the format shown below on //individuals participating in the project. Name Stephen D. Miller, Ph.D. Patricia Q. Spear, Ph.D. Michael Abecassis, M.D. Ashok Aiyar, Ph.D. Terrence A. Barrett, M.D. Nicholas Cianciotto, Ph.D. Neil A. Clipstone, Ph.D. Syamal K. Datta, M.D. David M. Engman, M.D., Ph.D. Organization Role on Project Department of Microbiology-Immunology Director Northwestern University Departmentof Microbiology-Immunology Co-Director Northwestern University Departmentof Surgery Assistant Preceptor Northwestern University Department of Microbiology-Immunology Assistant Preceptor NorthwesternUniversity Dept. of Medicine & Microbiology Preceptor Northwestern University Departmentof Microbiology-Immunology Preceptor Northwestern University Department of Microbiology-Immunology Preceptor NorthwesternUniversity Departmentof Medicine & Microbiology Preceptor Northwestern University Departmentof Pathology & Microbiology Preceptor Northwestern University PUS 398 (Rev. 4/98) Page 2 BB Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ========================================Section End===========================================
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