Despite advances in public health and medical therapeutics, infectious diseases continue to represent the leading cause of morbidity and mortality worldwide which extracts a considerable financial and societal toll even in developed countries due to factors such as emerging pathogens, AIDS or other immunocompromising conditions, and antimicrobial resistance. Between 1980 and 1992, the U.S. death rate from infectious diseases, excluding HIV/AIDS, rose by 22%. Infectious diseases are presently the third leading cause of death in the U.S. and the leading cause worldwide. Familiar bacterial pathogens such as Salmonella and Mycobacterium tuberculosis continue to contribute to the deaths of millions of people each year, while other pathogens such as Escherichia coli 0157:H7 and community-acquired Methicillin-Resistant Staphylococcus aureus have emerged as new threats. The recent specter of bioterrorism has only served to heighten concern that a better understanding of the pathogenesis of infection is needed. The training of new scientists who can elucidate basic mechanisms of microbial pathogenesis will be critical for the formulation of improved strategies to prevent, diagnose and treat infectious diseases. This application for renewed support of a Training Program in Bacterial Pathogenesis centers around an established and highly interactive interdisciplinary research community and the University of Washington. The goal of the program is to provide comprehensive interdisciplinary training and mentorship for pre- and post-doctoral trainees who seek to understand fundamental cellular and molecular mechanisms of the interactions between bacterial pathogens and their hosts. This training will ultimately allow them to obtain new scientific insights as independent investigators that can lead to novel approaches for the prevention and management of infectious diseases.
This is a program to provide research training to scientists who study bacterial infections such as typhoid and tuberculosis. An increased understanding of these conditions will be essential for the development of improved strategies for the prevention and treatment of human infections.
|Lang, Kevin S; Merrikh, Houra (2018) The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria. Annu Rev Microbiol 72:71-88|
|Abendroth, Jan; Frando, Andrew; Phan, Isabelle Q et al. (2018) Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein. Protein Sci 27:568-572|
|Ortega, Corrie; Frando, Andrew; Webb-Robertson, Bobbie-Jo et al. (2018) A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes. Mol Cell Proteomics 17:111-120|
|Urbano, Rodolfo; Karlinsey, Joyce E; Libby, Stephen J et al. (2018) Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence. Cell Host Microbe 23:594-606.e7|
|Pando, Jasmine M; Karlinsey, Joyce E; Lara, Jimmie C et al. (2017) The Rcs-Regulated Colanic Acid Capsule Maintains Membrane Potential in Salmonella enterica serovar Typhimurium. MBio 8:|
|Gall, Alevtina; Gaudet, Ryan G; Gray-Owen, Scott D et al. (2017) TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection. MBio 8:|
|Conrad, William H; Osman, Morwan M; Shanahan, Jonathan K et al. (2017) Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions. Proc Natl Acad Sci U S A 114:1371-1376|
|Madigan, Cressida A; Cambier, C J; Kelly-Scumpia, Kindra M et al. (2017) A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell 170:973-985.e10|
|Huynh, TuAnh Ngoc; Choi, Philip H; Sureka, Kamakshi et al. (2016) Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Mol Microbiol 102:233-243|
|Eshraghi, Aria; Kim, Jungyun; Walls, Alexandra C et al. (2016) Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host Microbe 20:573-583|
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