Immune responses are affected by environmental factors (infection, photoperiod, toxic chemicals), behavior (smoking, alcohol use, nutrition), hormones/neurotransmitters (sex/stress steroids and norepinephrine), and a variety of other influences. For example, the terrorist attacks of September 11, 2001, and the subsequent anthrax scare have affected, and will continue to affect, immune function in all individuals. The long-term consequences of that date on human health and disease are unknown, but are predicted to be significant. Understanding the mechanisms by which external forces influence immune function requires a multidisciplinary approach to studying the various factors that determine resistance and susceptibility to disease. The Ohio State University is internationally recognized for its faculty who are dedicated to studying the environmental and physiological variables that influence immune function, most notably the effects of stress, neurohormones, gender, behavior, and infection. The 13 faculty who will be contributing to this training program have a strong track record of predoctoral and postdoctoral training, and each provides trainees with centrally located state-of-the-art laboratories. Using a multidisiplinary approach that includes training in immunology, neuroscience, molecular biology, endocrinology, microbial pathogenesis, psychology, psychiatry, and pharmacology, trainees will study the cellular, biochemical, and molecular mechanisms by which immune homeostasis is influenced by the nervous and endocrine systems. Trainees will study the health consequences that result from dysregulation of these systems and observe firsthand, the integration of laboratory research with behavior and health outcomes. Candidates will be evaluated on the basis of past academic performance, letters of recommendation, scholarly work that includes publications and presentations, and a statement of personal goals. The training period will be three years for predoctoral and two years for postdoctoral fellows, depending on the extent of basic science training required for each trainee. In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease.
| Padro, Caroline J; Sanders, Virginia M (2014) Neuroendocrine regulation of inflammation. Semin Immunol 26:357-68 |
| Graham, Jennifer E; Song, Sunmi; Engeland, Christopher G (2012) Acute pain speeds skin barrier recovery in healthy men and women. J Psychosom Res 73:452-8 |
| Kiecolt-Glaser, Janice K; Christian, Lisa M; Andridge, Rebecca et al. (2012) Adiponectin, leptin, and yoga practice. Physiol Behav 107:809-13 |
| McAlees, Jaclyn W; Smith, Laura T; Erbe, Robert S et al. (2011) Epigenetic regulation of beta2-adrenergic receptor expression in T(H)1 and T(H)2 cells. Brain Behav Immun 25:408-15 |
| Christian, Lisa M; Glaser, Ronald; Porter, Kyle et al. (2011) Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrinology 36:1495-504 |
| Navara, Kristen J; Workman, Joanna L; Oberdick, John et al. (2010) Short day lengths skew prenatal sex ratios toward males in Siberian hamsters. Physiol Biochem Zool 83:127-34 |
| Christian, Lisa M; Franco, Albert; Iams, Jay D et al. (2010) Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant women. Brain Behav Immun 24:49-53 |
| Wynne, Angela M; Henry, Christopher J; Huang, Yan et al. (2010) Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun 24:1190-201 |
| Kiecolt-Glaser, Janice K; Christian, Lisa; Preston, Heather et al. (2010) Stress, inflammation, and yoga practice. Psychosom Med 72:113-21 |
| Graham, Jennifer E; Glaser, Ronald; Loving, Timothy J et al. (2009) Cognitive word use during marital conflict and increases in proinflammatory cytokines. Health Psychol 28:621-30 |
Showing the most recent 10 out of 32 publications
