The Training Program in Host-Pathogen Interactions (HPI) has been supported to train predoctoral students in the areas of microbial pathogenesis and host defense for the past 4 years. This revised renewal application seeks to build upon the many strengths that have been developed at UMCP over the initial support period and to expand our program in host-pathogen interactions. Our 23 training faculty are remarkably interactive, allowing our trainees to be exposed to a variety of diverse research techniques. Multi-disciplinary approaches to pathogen research will be emphasized to take advantage of our widespread expertise in diverse research areas including biomaterials and nanosciences, computational biology and genomics, microbiology and immunology, and microbial pathogenesis. Trainees in the HPI program will be exposed to a variety of career alternatives, and attend seminars from previous trainees who have gone on to pursue careers in clinical trials administration, scientific review, biodefense, intellectual property, science writing, and entrepreneurship. A new internship with MedImmune provides opportunity to explore Biopharma first-hand. The didactic component of this training program is organized by the Biological Sciences Training Program (BISI) and the research program is guided by a highly qualified team including the Training Program Co-Directors, an Internal Steering Committee, and an External Advisory Board comprised of internationally recognized experts in bacterial pathogenesis and host defense. Predoctoral students are selected for this program from a large and increasingly qualified applicant pool. Of the 14 trainees supported by the HPI Training Program two (2) are underrepresented minorities (15%), and 10/14 trainees were women. Of the 23 faculty trainers, 1 is an underrepresented minority and 5 are women (22%). This training program takes advantage of the close proximity of UMCP to the NIH, FDA, USAMRIID, and the Department of Homeland Security and we have sent students into laboratories from all of these institutions to learn techniques. Finally, our trainees present their research at local, national, and international meetings. Thus, the Training Program in Host-Pathogen Interactions plays a key role in the continued development of this discipline at the University of Maryland, College Park.

Public Health Relevance

In the future, our ability to fight new infectious diseases and to control immunological disorders will depend on the advanced training that our current graduate students receive. Our trainees will get exceptional multi-disciplinary training in the area of host-pathogen interactions to prepare them to meet these future challenges.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Coomes, Stephanie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland College Park
Anatomy/Cell Biology
Earth Sciences/Resources
College Park
United States
Zip Code
Bookstaver, Michelle L; Hess, Krystina L; Jewell, Christopher M (2018) Self-Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation. Small 14:e1802202
Bookstaver, Michelle L; Tsai, Shannon J; Bromberg, Jonathan S et al. (2018) Improving Vaccine and Immunotherapy Design Using Biomaterials. Trends Immunol 39:135-150
Nazario-Toole, Ashley E; Robalino, Javier; Okrah, Kwame et al. (2018) The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster. J Immunol 201:1154-1164
Ikonomova, Svetlana P; Le, Megan T; Kalla, Neha et al. (2018) Effect of linkers on immobilization of scFvs with biotin-streptavidin interaction. Biotechnol Appl Biochem 65:580-585
Ikonomova, Svetlana P; Moghaddam-Taaheri, Parisa; Jabra-Rizk, Mary Ann et al. (2018) Engineering improved variants of the antifungal peptide histatin 5 with reduced susceptibility to Candida albicans secreted aspartic proteases and enhanced antimicrobial potency. FEBS J 285:146-159
Rhoads, Melissa K; Hauk, Pricila; Gupta, Valerie et al. (2018) Modification and Assembly of a Versatile Lactonase for Bacterial Quorum Quenching. Molecules 23:
Goodson, Jonathan R; Klupt, Steven; Zhang, Chengxi et al. (2017) LoaP is a broadly conserved antiterminator protein that regulates antibiotic gene clusters in Bacillus amyloliquefaciens. Nat Microbiol 2:17003
Zhang, Peipei; Andorko, James I; Jewell, Christopher M (2017) Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates. Biotechnol Bioeng 114:423-431
Hamidzadeh, Kajal; Christensen, Stephen M; Dalby, Elizabeth et al. (2017) Macrophages and the Recovery from Acute and Chronic Inflammation. Annu Rev Physiol 79:567-592
Inbar, Ehud; Hughitt, V Keith; Dillon, Laura A L et al. (2017) The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector. MBio 8:

Showing the most recent 10 out of 41 publications