An unprecedented expansion of knowledge has occurred in modern immunology in the field of innate immunity over the last 15 years. The """"""""Signaling Pathways in Innate Immunity"""""""" (SPII) Training Program represents a revised, new T32 application to support 2 predoctoral and 2 postdoctoral trainees in this important and burgeoning area. The University of Maryland, School of Medicine (UMSOM) has significant research and training strengths in this area. The Training Grant Faculty (TGF) for this unique and highly focused program are drawn primarily from the Department of Microbiology and Immunology and several interdisciplinary centers and institutes at UMSOM including the Mucosal Biology Research Center, the Center for Vascular and Inflammatory Diseases, the Center for Vaccine Development, Greenebaum Cancer Center, and the Institute of Human Virology. All but one TGF are located within a 2-block distance of the Department of Microbiology &Immunology on the UMSOM campus. The TGF have a longstanding history of collaboration on grants and publications, and are well funded, with grants and contracts totaling ~$17.4 million in annual direct costs. Predoctoral trainees will be drawn primarily from the interdepartmental Graduate Program in Life Sciences (GPILS) Programs in Molecular Microbiology &Immunology (MMI) and Molecular Medicine (MM), established Ph.D. Programs that include a common core curriculum, program-specific courses, elective courses, journal clubs, seminars, annual symposia, and graduate research presentation days. Additional academic work will be combined with rigorous laboratory training through laboratory rotations and dissertation research under the direction of the TGF whose documented expertise will provide inter- and multidisciplinary training opportunities. Predoctoral students are selected from an increasingly qualified applicant pool, as well as from the UMSOM M.D./Ph.D. Program. Similarly, our Training Grant Eligible postdoctoral trainees are increasingly gravitating to laboratories with expertise in innate immune signaling. Both pre- and postdoctoral trainees will have additional didactic and non-didactic requirements, including training in the responsible conduct of research and professional development, as well as a highly structured mentoring program. Specific efforts are already in place to recruit trainees from underrepresented minorities. The program is guided by a highly qualified team including the Training Program Director, two Co-Directors, a Steering Committee, and an External Advisory Committee comprised of internationally recognized experts in innate immunity. We anticipate that our trainees will be extraordinarily well prepared for future careers in academia, government, and industry and will contribute in significant ways to basic and translational problems in this complex area of innate immunity.

Public Health Relevance

Our future ability to fight infection, diseases like arthritis, and cancer depends on advanced training of students so that they gain the analytical skills needed to connect the dots to unravel the complex biochemical reactions that underlie our earliest immune responses. Our trainees will get exceptional academic support and mentoring from our dedicated and highly experienced faculty.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Transplantation Biology &Immunology-2 (AITC)
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Prograis, Lawrence J
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University of Maryland Baltimore
Schools of Medicine
United States
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Henry, Rebecca J; Doran, Sarah J; Barrett, James P et al. (2018) Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice. Neurotherapeutics :
Gregg, Kelsey A; Harberts, Erin; Gardner, Francesca M et al. (2018) A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model. Vaccine 36:4023-4031
Rennoll, Sherri A; Rennoll-Bankert, Kristen E; Guillotte, Mark L et al. (2018) The Cat Flea (Ctenocephalides felis) Immune Deficiency Signaling Pathway Regulates Rickettsia typhi Infection. Infect Immun 86:
Corona, Abigail K; Jackson, William T (2018) Finding the Middle Ground for Autophagic Fusion Requirements. Trends Cell Biol 28:869-881
Balzano, Phillip M; Cunningham, Aimee L; Grassel, Christen et al. (2018) Deletion of the Major Facilitator Superfamily Transporter fptB Alters Host Cell Interactions and Attenuates Virulence of Type A Francisella tularensis. Infect Immun 86:
Venkataraman, Thiagarajan; Coleman, Christopher M; Frieman, Matthew B (2017) Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. J Virol 91:
Driscoll, Timothy P; Verhoeve, Victoria I; Guillotte, Mark L et al. (2017) Wholly Rickettsia! Reconstructed Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells. MBio 8:
Vasta, Gerardo R; Feng, Chiguang; González-Montalbán, Nuria et al. (2017) Functions of galectins as 'self/non-self'-recognition and effector factors. Pathog Dis 75:
Klontz, Erik H; Tomich, Adam D; Günther, Sebastian et al. (2017) Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother 61:
Bollino, Dominique; Webb, Tonya J (2017) Chimeric antigen receptor-engineered natural killer and natural killer T cells for cancer immunotherapy. Transl Res 187:32-43

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