Organ transplantation and cancer chemotherapy are life-saving interventions for an increasing number of patients. Despite important advances in surgical technique, immunosuppressive regimens, and the development of novel antimicrobial agents, these immunocompromised hosts remain at substantial risk for developing infections. Care of this complex patient population requires unique knowledge that differs from that of the general Infectious Diseases clinician. Accordingly, Transplant Infectious Diseases has emerged as a subspecialty within the field of Infectious Diseases (ID), and the American Society of Transplantation has developed a core curriculum for training specialists in Transplant ID. Duke University is uniquely poised to provide fellows with exceptional training in Transplant ID: Duke University Hospital is a major transplant and cancer care center with an active Transplant/Immunocompromised Host ID Service, ACGME-accredited Training Programs in ID and Medical Microbiology, and a highly qualified faculty committed to teaching fellows in the specialized area of Transplant ID including state-of-the-art methods of basic science and patient- oriented research. In fact, with minimal support over the past 10 years, the Duke ID Division has trained several successful young faculty who currently hold academic positions, specializing in Transplant ID care and research. The objective of this Training Program is to capitalize on the rich resources available at Duke in order to develop innovative ID physician-scientists trained in the care of immunocompromised hosts and the latest research methods. The combined research and clinical training program will occur after completion of at least one year of general clinical ID fellowship, which will include baseline Transplant ID experience. The Transplant ID core curriculum will include additional training in the clinical care of the transplant/immunocompromised host, training in laboratory medicine relevant to Transplant ID, and development of either basic or clinical research skills individualized to the trainee's expertise and career goals. Key areas for research training, as applicable to the Transplant/Immunocompromised host, will include: 1) laboratory medicine, 2) microbial epidemiology & pathogenesis, 3) host susceptibility & response to infection, and 4) medical management & treatment outcomes.
Infectious diseases are among the leading causes of death in immunocompromised hosts, especially those patients receiving organ and tissue transplantation. The specialized knowledge required for the care of this population differs from that emphasized among general Infectious Diseases clinicians. The proposed training program will address this significant gap in clinical practice by developing the next generation of leaders in the field of Transplant Infectious Diseases by training physician-scientists in the care of immunocompromised hosts and innovative methods of research to prepare them for independent academic careers.
| Hemmersbach-Miller, Marion; Stout, Jason E; Woodworth, Michael H et al. (2018) Nocardia infections in the transplanted host. Transpl Infect Dis 20:e12902 |
| DeFilipp, Zachariah; Peled, Jonathan U; Li, Shuli et al. (2018) Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity. Blood Adv 2:745-753 |
| Freischlag, Kyle William; Messina, Julia; Ezekian, Brian et al. (2018) Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes. Transplant Direct 4:e349 |
| Baker, Arthur W; Haridy, Salah; Salem, Joseph et al. (2018) Performance of statistical process control methods for regional surgical site infection surveillance: a 10-year multicentre pilot study. BMJ Qual Saf 27:600-610 |
| Hemmersbach-Miller, Marion; Bailey, Emily S; Kappus, Matthew et al. (2018) Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation. Front Cell Infect Microbiol 8:408 |
| Messina, Julia A; Sinha, Rohita; Starr, Kimberly et al. (2018) Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia. Open Forum Infect Dis 5:ofy107 |
| Messina, Julia A; Wolfe, Cameron R; Hemmersbach-Miller, Marion et al. (2018) Genomic characterization of recurrent mold infections in thoracic transplant recipients. Transpl Infect Dis 20:e12935 |
| Hemmersbach-Miller, Marion; Berg, Carl L; Messina, Julia A et al. (2018) Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report. Open Forum Infect Dis 5:ofy070 |
| Tie, Guodong; Yan, Jinglian; Khair, Lyne et al. (2017) Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and ?? T Cells from Hematopoietic Stem Cells. Cancer Res 77:2351-2362 |
| Baker, Arthur W; Lewis, Sarah S; Alexander, Barbara D et al. (2017) Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. Clin Infect Dis 64:902-911 |
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