Today's reality includes emergence and spread of multi-drug resistant organisms and new infectious agents, a growing concern for worldwide pandemics, the use of infectious agents in offensive bio-warfare, and an enlarging list of opportunistic infections. These challenges to human health necessitate comprehensive interdisciplinary training programs for the next generation of scientists in studies of the microbe host interface. The training faculty are from three colleges and several different departments. The hub for the program will be the Ohio State University Center for Microbial Interface Biology (CMIB), which is focused on Host-Pathogen Research. One of the PIs (MPI mechanism) is a physician scientist who serves as Director of the CMIB and Chair of a new Department in the Medical School, Microbial Infection and Immunity (MI&I), and the other PI is a PhD scientist and CMIB Vice-Director/MI&I Vice-Chair, both with strong research programs and careers focused on education. Thus the PIs represent an outstanding, established collaborative team to oversee this broad innovative program which emphasizes: 1) a highly interactive scientific community, 2) a multidisciplinary approach to science, 3) exposure of trainees to the biomedical research community of a large academic health sciences center, 4) integration of the clinical and basic sciences, 5) exposure to experienced and talented scientist educators and mentors, and 6) several added advantages to Fellows, including a local and international externship program. The major thematic areas are 1) Microbial response to infection;2) Host response to infection (immunity, respiratory biology);3) Biofilms;and 4) Drug discovery. The program describes a Selection and Oversight Committee, an outstanding, engaged External Advisory Committee and the necessary administrative structure to execute the program. Emphasis is placed on the recruitment of diversity trainees and on formal instruction for the responsible conduct of research. We request 3 pre-doctoral, 2 post-doctoral and 1 short-term clinical scholar slots/year. We believe that the curriculum, faculty, resources, and institutional support make this program attractive to outstanding students who will receive a unique multidisciplinary training experience focused on the microbe-host interface and prepare them for a career in the breadth of the biomedical workforce.

Public Health Relevance

It is important to ensure that the next generation of scientists includes those with an expertise in infectious diseases. This proposal will fund the training of students (predoctoral and postdoctoral) studying various aspects of host-pathogen interactions at The Ohio State University. Students entering the training program will receive a unique, multidisciplinary training experience to best prepare them for an ever-changing workforce.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-FDS-M (M5))
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Ohio State University
Schools of Medicine
United States
Zip Code
Gregory, Ann C; Sullivan, Matthew B; Segal, Leopoldo N et al. (2018) Smoking is associated with quantifiable differences in the human lung DNA virome and metabolome. Respir Res 19:174
Garfoot, Andrew L; Goughenour, Kristie D; Wüthrich, Marcel et al. (2018) O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures. MBio 9:
Lam, Jonathan G T; Vadia, Stephen; Pathak-Sharma, Sarika et al. (2018) Host cell perforation by listeriolysin O (LLO) activates a Ca2+-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes Listeria monocytogenes internalization independently of membrane resealing. Mol Biol Cell 29:270-284
Howard-Varona, Cristina; Hargreaves, Katherine R; Solonenko, Natalie E et al. (2018) Multiple mechanisms drive phage infection efficiency in nearly identical hosts. ISME J 12:1605-1618
Kang, Dae-Wook; Adams, James B; Gregory, Ann C et al. (2017) Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome 5:10
Garfoot, Andrew L; Dearing, Kacey L; VanSchoiack, Andrew D et al. (2017) Eng1 and Exg8 Are the Major ?-Glucanases Secreted by the Fungal Pathogen Histoplasma capsulatum. J Biol Chem 292:4801-4810
Goughenour, Kristie D; Rappleye, Chad A (2017) Antifungal therapeutics for dimorphic fungal pathogens. Virulence 8:211-221
Arcos, J; Sasindran, S J; Moliva, J I et al. (2017) Mycobacterium tuberculosis cell wall released fragments by the action of the human lung mucosa modulate macrophages to control infection in an IL-10-dependent manner. Mucosal Immunol 10:1248-1258
Hill, Preston J; Scordo, Julia M; Arcos, Jesús et al. (2017) Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells. Sci Rep 7:4761
Pathak-Sharma, Sarika; Zhang, Xiaoli; Lam, Jonathan G T et al. (2017) High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and Repair. Front Cell Infect Microbiol 7:305

Showing the most recent 10 out of 17 publications