The goal of this program at Washington University is to provide high quality research training in the biomedical investigation of the rheumatic diseases, with a focus on the characterization of basic immunological mechanisms. Now in its 31st year, the program has developed a research training environment conducive to the nurturing of young scientists as evidenced by the large number of researchers and academics who have trained here. The experience will occur under the direction of training faculty in six major areas relevant to the immunobiology of inflammatory diseases including: 1) Animal models of rheumatic diseases;2) Autoimmunity and tolerance;3) Inflammation, the complement system and the innate immune response;4) Antigen processing and MHC molecules 5) Immunoregulation and host defense;and 6) Receptor signaling and lymphocyte development. These predominantly bench investigations in a mentor's laboratory will explore the mechanisms of human and mouse immune and inflammatory responses. A goal of these studies and one that we have fulfilled in the past is to translate these bench based observations into meaningful explanations for the etiology and immunopathologic basis of human disease states. Training Faculty include primarily members of the Rheumatology Division in the Department of Medicine and of the Department of Pathology and Immunology. Both physician-scientist (M.D. and M.D., Ph.D.) and basic scientist (Ph.D.) preceptors form the Program Faculty who are dedicated to training the next generation of scientists dedicated to increasing our understanding of the immunobiology of inflammatory diseases. Trainees will also be required to attend seminars and conferences that are devoted to clinical and translational aspects of rheumatology. This aspect of the training program provides exposure to clinical issues and points out opportunities for new research directions. Thus, this program has a distinguished track record of training physician-scientists and will continue to produce high quality researchers interested in immunologic aspects of the rheumatic diseases.
| Kulkarni, Hrishikesh S; Witt, Chad A (2018) Voriconazole in lung transplant recipients - how worried should we be? Am J Transplant 18:5-6 |
| Kulkarni, Hrishikesh S; Elvington, Michelle L; Perng, Yi-Chieh et al. (2018) Intracellular C3 Protects Human Airway Epithelial Cells from Stress-Associated Cell Death. Am J Respir Cell Mol Biol : |
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| Liszewski, M Kathryn; Elvington, Michelle; Kulkarni, Hrishikesh S et al. (2017) Complement's hidden arsenal: New insights and novel functions inside the cell. Mol Immunol 84:2-9 |
| Elvington, Michelle; Liszewski, M Kathryn; Bertram, Paula et al. (2017) A C3(H20) recycling pathway is a component of the intracellular complement system. J Clin Invest 127:970-981 |
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| Schmid, Edward T; Pang, Iris K; Carrera Silva, Eugenio A et al. (2016) AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife 5: |
| Elvington, Michelle; Liszewski, M Kathryn; Atkinson, John P (2016) Evolution of the complement system: from defense of the single cell to guardian of the intravascular space. Immunol Rev 274:9-15 |
| Speer, Scott D; Li, Zhi; Buta, Sofija et al. (2016) ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun 7:11496 |
| Miner, Jonathan J; Diamond, Michael S (2016) Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier. Curr Opin Immunol 38:18-23 |
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