In this project neuroendocrine regulation is being studied in patients with psychiatric disorders, with a particular emphasis on patients with endogenous depression (ED) or melancholia. Patients with ED have specific disturbances of limbic system-pituitary-adrenocortical regulation, revealed most clearly by the overnight 24h dexamethasone suppression test (DST). The DST is being validated as an independent laboratory validating marker of ED, and various parameters of the test are being studied to improve the diagnostic performance. The neurotransmitter mechanism of the abnormal DST response is being studied as well, with a view to obtaining in vivo evidence relevant to the possible neurotransmitter mechanism of ED.
| Cassidy, F; Ritchie, J C; Carroll, B J (1998) Plasma dexamethasone concentration and cortisol response during manic episodes. Biol Psychiatry 43:747-54 |
| Krishnan, K R; Ritchie, J C; Manepalli, A N et al. (1991) Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression. Prog Neuropsychopharmacol Biol Psychiatry 15:637-42 |
| Kayganich, K; Watson, J T; Kilts, C et al. (1990) Determination of plasma dexamethasone by chemical oxidation and electron capture negative ionization mass spectrometry. Biomed Environ Mass Spectrom 19:341-7 |
| Ritchie, J C; Belkin, B M; Krishnan, K R et al. (1990) Plasma dexamethasone concentrations and the dexamethasone suppression test. Biol Psychiatry 27:159-73 |
| Rao, V P; Krishnan, K R; Goli, V et al. (1989) Neuroanatomical changes and hypothalamo-pituitary-adrenal axis abnormalities. Biol Psychiatry 26:729-32 |
| Lee, M A; Flegel, P; Cameron, O G et al. (1988) Chronic caffeine consumption and the dexamethasone suppression test in depression. Psychiatry Res 24:61-5 |
| Lee, M A; Flegel, P; Greden, J F et al. (1988) Anxiogenic effects of caffeine on panic and depressed patients. Am J Psychiatry 145:632-5 |
| Cameron, O G; Thomas, B; Tiongco, D et al. (1987) Hypercortisolism in diabetes mellitus. Diabetes Care 10:662-4 |
| Grunhaus, L; Zelnik, T; Albala, A A et al. (1987) Serial dexamethasone suppression tests in depressed patients treated only with electroconvulsive therapy. J Affect Disord 13:233-40 |
| Kumar, A; Shipley, J E; Eiser, A S et al. (1987) Clinical correlates of sleep onset REM periods in depression. Biol Psychiatry 22:1477-81 |
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