This revised application for a comprehensive Research Training Program in Bone Biology and Disease at UAB offers the rigorous interdisciplinary education required for the development of independent research scientists in this field. The Training Program is based in the UAB Center for Metabolic Bone Disease (Director: J. McDonald, M.D.), which has been funded as 1 of 5 national Research Core Centers (P30). The 25 faculty members of the Training Program have been selected based on their complementary research expertise in clinical and basic research, dynamic research programs, and training records. Due to the interdisciplinary nature of the Program, the faculty has defined collaborative projects (58) that are available immediately and can be used in recruitment and guidance. Basic research projects include the use of approaches and technologies in the analysis of the basic biology of bone loss; osteoporosis, other metabolic bone diseases, and glucocorticoid induced bone loss; periodontal disease; cancer metastatic to bone; and biomaterials/implant research. The clinical research projects (epidemiology, prevention, outcomes, and effectiveness studies; development of diagnostics; and clinical trials) exploit the participation of clinical faculty in long term, multi institutional studies, including geriatric and pediatric populations. The Training Program will be administered by Dr. McDonald (Chair: Pathology) assisted by two Associate Directors (T. Lincoln, Ph.D.; L. Moreland, M.D.), who will be responsible for development of individual training plans, integration of research and didactic components, and oversight of formal requirements, and an Advisory Committee (M. Jeffcoat, D.M.D., L. Lucas, Ph.D., R. Mayne, Ph.D., J. Murphy Ulrich, Ph.D., K. Saag, M.D.), who will be responsible for recruitment, competitive review of formal applications, and oversight of trainees progress. Trainees in basic research will be required to take all or part of the Integrative Biomedical Sciences Program (Director: Lincoln), which provides organ and cell based basic science training necessary for transition from methods driven molecular biology and genetics analyses into clinically relevant, problem based studies. The K30 Translational Research Program (PI: Moreland) provides clinical investigators with the intellectual and administrative skills essential for the design and accomplishment of informative clinical studies and trials, together with a background in state of the art basic science knowledge. Funding is requested for three predoctoral and three postdoctoral trainees. Predoctoral trainees will be enrolled in the IBS, Biomedical Engineering, Cell and Molecular Biology, or M.D./Ph.D. Graduate Programs at UAB.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Sharrock, William J
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University of Alabama Birmingham
Schools of Medicine
United States
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Khotskaya, Yekaterina B; Beck, Benjamin H; Hurst, Douglas R et al. (2014) Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog 53:1011-26
Wang, Ying; Cox, Megan K; Coricor, George et al. (2013) Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation. Dev Biol 382:27-37
Grunda, Jessica M; Wang, Dezhi; Clines, Gregory A (2013) Development and characterization of murine models of medulloblastoma extraneural growth in bone. Clin Exp Metastasis 30:769-79
Sharma, Neeraj; Malarkey, Erik B; Berbari, Nicolas F et al. (2013) Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption. J Am Soc Nephrol 24:456-64
Wang, Ying; Serra, Rosa (2012) PDGF mediates TGFýý-induced migration during development of the spinous process. Dev Biol 365:110-7
Jules, Joel; Zhang, Ping; Ashley, Jason W et al. (2012) Molecular basis of requirement of receptor activator of nuclear factor ?B signaling for interleukin 1-mediated osteoclastogenesis. J Biol Chem 287:15728-38
Croyle, Mandy J; Lehman, Jonathan M; O'Connor, Amber K et al. (2011) Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138:1675-85
Ashley, Jason W; Shi, Zhenqi; Zhao, Haibo et al. (2011) Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. PLoS One 6:e25838
Ashley, Jason W; McCoy, Erin M; Clements, Daniel A et al. (2011) Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. Assay Drug Dev Technol 9:40-9
Ritchie, Joseph P; Ramani, Vishnu C; Ren, Yongsheng et al. (2011) SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res 17:1382-93

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