The Orthopaedic Research Center of The Cleveland Clinic Foundation (CCF) plans a coordinated, training effort for which we request 2 pre-doctoral and 2 post-doctoral scientists, one clinician- scientist, and three 12 week research experiences for medical students in Year 1. Investigators and clinician/scientists from the Departments of Biomedical Engineering and Orthopaedic Surgery are already actively collaborating in 3 broad areas: (1) bone biology and biomechanics, (2) soft tissue biology and biomechanics, (3) joint and whole-body biomechanics. These highly interactive areas offer substantial opportunities for didactic and bench-level training in areas ranging from cell/molecular biological techniques to in vivo or in vitro models and clinical research projects. Recruitment plans include incentives for a post-residency clinician-scientist to participate in one of a rich array of clinical-basic science partnerships. We outline the projected organizational and administrative structures necessary to ensure the success of these training opportunities. In addition to focused activities in each of the three topic areas, a range of integrative activities are planned to build upon an established record of education and training in the orthopaedic sciences at CCF. These include a 40-lecture basic science curriculum, two seminar series, bioethics and biostatistics lectures, grant preparation workshops, inventorship forums, teaching opportunities, and mandatory abstract submission to professional meetings. Institutional support will be provided for the saries of the program directors and mentors, and for books and journals and for salary supplementation for the clinician-scientist. The goals outlined in this proposal align closely with the institution's efforts to encourage clinical and translational research in a General Clinical Research Center (approved in early 2003) and in the new Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, a research-based, 5-year program that will admit its first class in 2004.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Panagis, James S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cleveland Clinic Lerner
Other Basic Sciences
Schools of Medicine
United States
Zip Code
Heylman, Christopher M; Santoso, Sharon; Krebs, Melissa D et al. (2014) Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. Med Biol Eng Comput 52:321-30
Heylman, Christopher M; Caralla, Tonya N; Boehm, Cynthia A et al. (2013) Slowing the Onset of Hypoxia Increases Colony Forming Efficiency of Connective Tissue Progenitor Cells In Vitro. J Regen Med Tissue Eng 2:
Petre, Marc; Erdemir, Ahmet; Panoskaltsis, Vassilis P et al. (2013) Optimization of nonlinear hyperelastic coefficients for foot tissues using a magnetic resonance imaging deformation experiment. J Biomech Eng 135:61001-12
Bartsch, Adam J; Benzel, Edward C; Miele, Vincent J et al. (2012) Boxing and mixed martial arts: preliminary traumatic neuromechanical injury risk analyses from laboratory impact dosage data. J Neurosurg 116:1070-80
Chin, Likang; Calabro, Anthony; Walker, Esteban et al. (2012) Mechanical properties of tyramine substituted-hyaluronan enriched fascia extracellular matrix. J Biomed Mater Res A 100:786-93
Bartsch, Adam; Benzel, Edward; Miele, Vincent et al. (2012) Hybrid III anthropomorphic test device (ATD) response to head impacts and potential implications for athletic headgear testing. Accid Anal Prev 48:285-91
Chin, Likang; Calabro, Anthony; Rodriguez, E Rene et al. (2011) Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix. J Mater Sci Mater Med 22:1465-77
Kutz, Wendy E; Wang, Lauren W; Bader, Hannah L et al. (2011) ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem 286:17156-67
Bey, Michael J; Kline, Stephanie K; Baker, Andrew R et al. (2011) Estimation of dynamic, in vivo soft-tissue deformation: experimental technique and application in a canine model of tendon injury and repair. J Orthop Res 29:822-7
McCarron, Jesse A; Milks, Ryan A; Chen, Xi et al. (2010) Improved time-zero biomechanical properties using poly-L-lactic acid graft augmentation in a cadaveric rotator cuff repair model. J Shoulder Elbow Surg 19:688-96

Showing the most recent 10 out of 19 publications