We propose to establish the UCLA Dermatology Scientist Training Program (DermSTP) with the goal to ensure the development of the next generation of academic leaders in investigative dermatology. The training program will leverage the UCLA STAR (Specialty Training and Advanced Research) program, which combines clinical and research training with a core curriculum and protected research time. The UCLA Dermatology STAR program has a proven track record with three graduates having received NIH K08 awards, three receiving NIH ROI awards, and nine having achieved academic positions. The UCLA DermSTP will also recruit outstanding M.D. and Ph.D. scientists as trainees, who propose research training in skin biology with the long term goal of developing a career in investigative dermatology. The UCLA DermSTP will raise awareness of the challenges and opportunities in skin diseases research, increasing the breadth of UCLA scientists interested in such research who wish to initiate their own projects in skin biology. The UCLA DermSTP will have the advantage of being located at one of the premier medical centers in the United States - the UCLA David Geffen School of Medicine is ranked 11th in total NIH funding and is noted for its richly diverse scientific strengths. The UCLA DermSTP will foster maximally effective collaboration among the researchers in the Division of Dermatology and will interconnect basic science research and translational application. Three postdoctoral fellows will be selected each year, with the expectation that trainees will apply for and receive at least one renewal year, to a maximum of three years. The experience will include mentoring by the principal investigator as well as the other training faculty, through a series of educational programs including trainee seminars, seminars by scientists from outside and within UCLA that are involved in skin disease research and journal clubs. In summary, the UCLA SDRC will provide a mechanism to further the growth and development of STAR trainees and other UCLA faculty, as well as training to outstanding medical students, graduate students, residents and fellows developing a career in skin disease research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR058921-02
Application #
8063061
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Cibotti, Ricardo
Project Start
2010-05-01
Project End
2015-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
2
Fiscal Year
2011
Total Cost
$170,081
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Shin, Daniel Sanghoon; Zaretsky, Jesse M; Escuin-Ordinas, Helena et al. (2017) Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. Cancer Discov 7:188-201
Yu, Yang; Champer, Jackson; Agak, George W et al. (2016) Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes. J Invest Dermatol 136:2221-2228
Zaretsky, Jesse M; Garcia-Diaz, Angel; Shin, Daniel S et al. (2016) Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. N Engl J Med 375:819-29
Ribas, Antoni; Shin, Daniel Sanghoon; Zaretsky, Jesse et al. (2016) PD-1 Blockade Expands Intratumoral Memory T Cells. Cancer Immunol Res 4:194-203
Griffin, Donald R; Weaver, Westbrook M; Scumpia, Philip O et al. (2015) Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Nat Mater 14:737-44
Shin, Daniel Sanghoon; Ribas, Antoni (2015) The evolution of checkpoint blockade as a cancer therapy: what's here, what's next? Curr Opin Immunol 33:23-35
Teles, Rosane M B; Kelly-Scumpia, Kindra M; Sarno, Euzenir N et al. (2015) IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol 135:2410-2417
Schmidt, Nathan W; Agak, George W; Deshayes, Stephanie et al. (2015) Pentobra: A Potent Antibiotic with Multiple Layers of Selective Antimicrobial Mechanisms against Propionibacterium Acnes. J Invest Dermatol 135:1581-1589
Yang, Bin; Treweek, Jennifer B; Kulkarni, Rajan P et al. (2014) Single-cell phenotyping within transparent intact tissue through whole-body clearing. Cell 158:945-958
Griffin, Donald R; Borrajo, Jacob; Soon, Allyson et al. (2014) Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. Chembiochem 15:233-42

Showing the most recent 10 out of 16 publications