This post-doctoral fellowship program is designed to train dermatologists and basic scientists who desire a thorough grounding in one or more of the following broad disciplines: biochemistry, cell biology, enzymology, genetics, immunology, microbiology, molecular biology, morphology, and photobiology. The basic aim of training is to provide an environment in which outstanding fellows can learn to be independent researchers in cutaneous biology. This goal will be accomplished through a mentored laboratory experience coupled with an intensive educational enrichment program. The thrust of our postdoctoral research training is that committed individuals spend a minimum of 2 years in a basic research laboratory and receive general and specialized instruction in the techniques of the laboratory by working on a well conceived problem with one or more mentors. During this time they will also be instructed in critical thinking, writing and presentation skills, the peer-review process and th responsible conduct of research. Trainees can choose research areas under the mentorship of senior scientists, either in the Department of Dermatology or in other departments (Cell and Molecular Biology, Chemistry, Medicine, Microbiology and Immunology, Pathology, or Pediatrics). Examples of research are: cell adhesion, cell motility, cell proliferation and differentiation, cutaneous immunology, epithelial stem cell biology, experimental carcinogenesis, extracellular matrix biology, inflammation, RNA silencing, signal transduction, wound healing and viral pathogenesis. The training sites on the Chicago and Evanston campuses provide state-of-the-art resources and facilities within individual laboratories and shared resources, including the Skin Disease Research Center. In addition to """"""""in lab training"""""""", a major focal point of the program centers around educational enrichment activities. Trainees will attend and participate in seminar series such as the """"""""Bench to Bedside"""""""" lecture series, the Epithelial Biology Group, basic science journal clubs, laboratory """"""""Works in Progress"""""""" meetings, a Wound Healing and Fibrosis series and the Grand Rounds lecture series organized through the Department of Dermatology. Our first priority will be to enroll physician/scientists who have completed their residency in dermatology and hold either an M.D./Ph.D. or an M.D. degree. We will also consider Ph.D. scientists. Candidates will be carefully selected to include only those with outstanding academic records, who show considerable interest and commitment to cutaneous research and desire to continue in academic dermatology. Given the sustained strengthening of the Department of Dermatology, including the awarding of a Skin Disease Research Center, and a dramatic increase in dermatology residents with M.D./Ph.D. degrees, the time is right for formal support of a Post Graduate Training Program in Cutaneous Biology.
The continued increase in sophistication of investigative techniques has revealed the vast complexity of skin and skin disorders, and has led to novel therapeutic approaches to manage disorders with cutaneous manifestations. To effectively harness such knowledge and bring it to the bedside, there is a dramatic need for well-trained physician/scientists and/or scientists with a thorough grounding in both bench and translational research to serve as the next generation of academicians in dermatology and cutaneous biology. Post Graduate Training Programs in Cutaneous Biology provide a means to develop these academic dermatologists.
|Nekrasova, Oxana; Harmon, Robert M; Broussard, Joshua A et al. (2018) Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination. Nat Commun 9:1053|
|Zhou, Xiaolong Alan; Louissaint Jr, Abner; Wenzel, Alexander et al. (2018) Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type. J Invest Dermatol 138:2365-2376|
|Perez White, Bethany E; Ventrella, Rosa; Kaplan, Nihal et al. (2017) EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions. J Cell Sci 130:111-118|
|Broussard, Joshua A; Yang, Ruiguo; Huang, Changjin et al. (2017) The desmoplakin-intermediate filament linkage regulates cell mechanics. Mol Biol Cell 28:3156-3164|
|Zhou, Xiaolong Alan; Chae, Young Kwang; Giles, Francis Joseph (2017) Developmental Therapeutics Implications of Next-Generation Sequencing in Human Herpesvirus 8-Negative Castleman Disease. JAMA Dermatol 153:381-382|
|Dam, Duncan Hieu M; Wang, Xiao-Qi; Sheu, Sarah et al. (2017) Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility. J Invest Dermatol 137:440-448|
|Zhou, Xiaolong Alan; Choi, Jaehyuk (2017) Photopheresis: Advances and Use in Systemic Sclerosis. Curr Rheumatol Rep 19:31|
|Bhattacharyya, Swati; Wang, Wenxia; Graham, Lauren Van Duyn et al. (2016) A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator. Arthritis Res Ther 18:216|
|Broussard, Joshua A; Getsios, Spiro; Green, Kathleen J (2015) Desmosome regulation and signaling in disease. Cell Tissue Res 360:501-12|
|Marangoni, Roberta Goncalves; Korman, Benjamin D; Wei, Jun et al. (2015) Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis Rheumatol 67:1062-73|
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