This application seeks to establish a Dermatology Investigator Training Program at the University of California, San Diego (UCSD) to train promising pre-doctoral and post- doctoral students and prepare them for a productive academic career in investigative dermatology. Skin research at UCSD has been extraordinarily productive in recent years and we have organized outstanding faculty with a proven track record in mentorship and conducting ground-breaking cutting edge research in skin biology. The goals of this program are to take advantage of our unparalleled institutional scientific resources, a well-funded base of dermatology research faculty and outstandingly equipped centralized modern laboratory space of over 8000 sq. ft. Our program proposes to use these to train much-needed future independent research investigators in skin biology. Our core dermatology faculty will be assisted in training by a network of actively collaborating basic science investigators that have a proven publication record in dermatology and a long history of successful mentorship. Together, these scientific faculty will immediately provide us with a critical mass of pre-doctoral and post-doctoral students to drive a vibrant training program. The UCSD Dermatology Investigator Training Program will be further enriched by a formalized co-mentorship program with outstanding clinical investigators, thus propelling PhD student research into opportunities for translational application of basic research projects. Emphasis will be placed in our leadership in conducting research in skin inflammation, infection and epidermal genetics and development. Promising trainees will be identified by an active recruitment program for physician-scientists, women and minorities, an active seminar and didactic series, and ongoing enrichment programs within the San Diego biomedical community. These strengths will ensure our ultimate goal to inspire and provide outstanding training for the next generation of academic researchers in investigative dermatology.

Public Health Relevance

The Dermatology Investigator Training Program at UCSD will leverage the outstanding scientific environment of one of the top research universities in the nation, and combine this with a productive translational program in dermatology. Our goal is to address a shortage of qualified investigators involved in skin disease research and thus decrease morbidity and mortality among a large population suffering from dermatologic disorders.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Cibotti, Ricardo
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University of California San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
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Williams, Michael R; Nakatsuji, Teruaki; Sanford, James A et al. (2017) Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes. J Invest Dermatol 137:377-384
Kulkarni, Nikhil N; Adase, Christopher A; Zhang, Ling-Juan et al. (2017) IL-1 Receptor-Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response after Exposure to UVB Radiation. J Invest Dermatol 137:2417-2426
Bochner, Ron; Samuelov, Liat; Sarig, Ofer et al. (2017) Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis. J Invest Dermatol 137:385-393
Li, Fengwu; Adase, Christopher A; Zhang, Ling-Juan (2017) Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin. J Vis Exp :
Sato, Emi; Zhang, Ling-Juan; Dorschner, Robert A et al. (2017) Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol 137:1774-1783
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Adase, Christopher A; Borkowski, Andrew W; Zhang, Ling-Juan et al. (2016) Non-coding Double-stranded RNA and Antimicrobial Peptide LL-37 Induce Growth Factor Expression from Keratinocytes and Endothelial Cells. J Biol Chem 291:11635-46
Zhang, Ling-Juan; Sen, George L; Ward, Nicole L et al. (2016) Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-? Production by Epidermal Keratinocytes during Skin Injury. Immunity 45:119-30
Sato, Emi; Muto, Jun; Zhang, Ling-Juan et al. (2016) The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol 136:1449-1459
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