The proposed program is designed to train postdoctoral researchers in biomedical research in the area of rheumatic diseases. We are requesting 3 postdoctoral training slots (for MD, MD/PhD, MD/MPH, and/or PhD researchers in bench laboratory or clinical-translational investigation), and 2 slots for predoctoral students (for dual MD/PhD and/or single PhD students, all to be trained in basic-translational research in the UCSD/La Jolla Institute for Allergy and Immunology (LJI) Biomedical sciences Program in Immunology). The training program will consist of a research experience typically of 24 months, and up to 36 months. Training is under close supervision of mentors collaboratively working on immunologic, molecular biologic, biochemical, and/or epidemiologic, health services, genetic, bioinformatic, and computational biologic problems relevant to the rheumatic diseases. Our emphasis is on recruiting and training new independent researchers to generate novel translational approaches and targeted therapies to rheumatic diseases, and to contribute to the pipeline of new leaders in Rheumatology research. Development of creative thinking, publication and presentation skills, along with inter-disciplinary team mentoring, and developing and improving faculty mentoring skills, are major features of the program. We will mesh complementary expertise and resources of more than one preceptor, tailored to individual trainees and research projects. All trainees are required to take courses in scientific ethics and scientific research methodology appropriate to their training and development. Other formal academic course work is encouraged for those carrying out basic research. MD trainees without an advanced degree in clinical research methodology are offered coursework to obtain a Master's Degree in Clinical Research (in the UCSD CTSA U54) or an MPH from the UCSD Department of Epidemiology. To help foster longstanding career commitment to research in subjects relevant to rheumatic diseases, all trainees will participate in Rheumatology research community-building, and San Diego community outreach. Non-MD trainees will take the medical school preclinical Rheumatology course, which includes encounters with patients. Trainees will be chosen on the basis of their prior academic performance, research career potential and experience, publications, interviews, and recommendations from supervisors. Preference is given to those with acknowledged research interests in rheumatologic and immunologic diseases, and demonstrated capacities in research. To address unmet needs, we will emphasize recruiting outstanding physician, MSTP, and URM student candidates. The primary training unit is the UCSD Rheumatology, Allergy and Immunology Division, UCSD. Additional training sites include UCSD and VA hospitals and clinics, the UCSD CTSA, and other UCSD Medicine Divisions and Departments, and labs at LJI and Sanford Burnham Prebys Medical Discovery Institute. Program graduates will be primed to compete for academic positions as independent investigators in medical schools or research institutes, or as research scientists in industry.

Public Health Relevance

The proposed renewal of the UCSD T32 program will provide resources and infrastructure to recruit and train a new generation of postdoctoral MD, MD/PhD, MD/MPH, and PhDs (3 training slots), as well predoctoral students early in their research careers (2 training slots for single PhD students in the UCSD/La Jolla Institute (LJI) Immunology track, and dual MD/PhD UCSD MSTP students aligned in Immunology). Our objective is to develop independent researchers and leaders in the field of rheumatic diseases, using inter-disciplinary approaches and the unique, multi-departmental, multi-institutional resources and environment of the UCSD and La Jolla research community. Graduates of this T32 program will be primed to address unmet needs, by creating advances in clinical medicine, therapies, and outcomes that improve the lives of rheumatic disease patients.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Mao, Su-Yau
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California, San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
Zip Code
Smith, Chelsey J F; Chambers, Christina D (2018) Five successful pregnancies with antenatal anakinra exposure. Rheumatology (Oxford) :
Smith, Chelsey J F; Jones, Kenneth L; Johnson, Diana L et al. (2018) Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions. Am J Med Genet A 176:570-577
Woller, Sarah A; Choi, Soo-Ho; An, Eun Jung et al. (2018) Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Rep 23:2667-2677
Chandra, Shilpi; Gray, James; Kiosses, William B et al. (2018) Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae. Nat Commun 9:4279
Chen, L-Y; Wang, Y; Terkeltaub, R et al. (2018) Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function. Osteoarthritis Cartilage 26:1539-1550
Shadyab, A H; Terkeltaub, R; Kooperberg, C et al. (2018) Prospective associations of C-reactive protein (CRP) levels and CRP genetic risk scores with risk of total knee and hip replacement for osteoarthritis in a diverse cohort. Osteoarthritis Cartilage 26:1038-1044
Smith, Chelsey J F; Förger, Frauke; Bandoli, Gretchen et al. (2018) Factors associated with preterm delivery among women with rheumatoid arthritis and juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) :
Zhao, Meng; Svensson, Mattias N D; Venken, Koen et al. (2018) Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat Commun 9:2627
Shadyab, Aladdin H; Eaton, Charles B; Li, Wenjun et al. (2018) Association of Physical Activity with Late-life Mobility Limitation among Women with Total Joint Replacement for Knee or Hip Osteoarthritis. J Rheumatol 45:1180-1187
Shadyab, Aladdin H; Li, Wenjun; Eaton, Charles B et al. (2018) General and Abdominal Obesity as Risk Factors for Late-Life Mobility Limitation After Total Knee or Hip Replacement for Osteoarthritis Among Women. Arthritis Care Res (Hoboken) 70:1030-1038

Showing the most recent 10 out of 29 publications