The scientists of the Pennington Biomedical Research Center, LSU Ag Center, and the Biotech Center at Rutgers, as part of their collaboration in the BRC, are committed to training in research.
A specific aim of the BRC is to expand the critical mass of investigators addressing botanical research by identifying, recruiting, and mentoring promising young investigators. Thus, a resubmission research training program application titled, """"""""Training in Botanical Approaches to Combat Metabolic Syndrome"""""""" is proposed for the BRC. The objective of this proposed training grant is to train both Ph.D. and M.D. postdoctoral fellows who possess graduate training in research methods and laboratory techniques to become productive research scientists capable of establishing scientific careers that further the efforts to understand the role of botanicals on the complex interactions between genetic, molecular and physiological aspects of the metabolic syndrome. Today's researchers need to understand the applications of the molecular and genetic approaches as well as the methods for investigating the function of target genes and the effect specific botanicals may have on these processes. It is difficult to get such a wide oversight or expertise during predoctoral programs. Hence, it is important to provide opportunities at the postdoctoral level for training in complementary areas. Our postdoctoral training will be directed towards this goal, enhancing research interactions between botanical characterization and molecular/genetic/physiologic approaches at both the basic science and clinical research areas. Specifically, we aim to bridge the divide between the plant discovery/characterization approach and the molecular biology/physiological approach. We are requesting 14 full-time Ph.D. or M.D. postdoctoral trainee stipends for the five-year grant period. Trainees will be supported for two to three years. We are requesting five full-time postdoctoral trainee stipends for the initial year of the grant;two entry level and three third year postdocs. Each postdoctoral fellow will be encouraged to develop interdisciplinary research efforts to understand the effect and action of botanicals on components of the metabolic syndrome. The program will take advantage of the cutting-edge technologies and the wide range of research efforts related to botanicals and metabolic syndrome that are available at the Pennington Center and the Biotech Center at Rutgers. This broad-based training program will enable trainees to establish successful research careers in academia, academic medicine, government agencies and in the private sector in the study of botanicals and metabolic disease.

Public Health Relevance

Metabolic syndrome is defined as a condition whose major features consist of obesity, insulin resistance, and development of type 2 diabetes. Metabolic syndrome is now reaching epidemic proportions worldwide, and it represents one of the most important public health problems today. The Botanicals Research Center (BRC) is dedicated to providing a comprehensive evaluation of botanicals in addressing the pathophysiologic mechanisms that lead to the development of insulin resistance and the metabolic syndrome.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1-LD (28))
Program Officer
Rivera-Rentas, Alberto L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Lsu Pennington Biomedical Research Center
Organized Research Units
Baton Rouge
United States
Zip Code
Rebello, Candida J; Johnson, William D; Martin, Corby et al. (2018) Effect of Two Oat-based Cereals on Subjective Ratings of Appetite. Curr Top Nutraceutical Res 16:113-120
Kim, Youjin; Jaja-Chimedza, Asha; Merrill, Daniel et al. (2018) A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats. Toxicol Rep 5:418-426
Coulter, Ann A; Rebello, Candida J; Greenway, Frank L (2018) Centrally Acting Agents for Obesity: Past, Present, and Future. Drugs 78:1113-1132
Rebello, Candida J; Nikonova, Elena V; Zhou, Sharon et al. (2018) Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy. Obesity (Silver Spring) 26:332-339
Allerton, Timothy D; Earnest, Conrad P; Johannsen, Neil M (2018) Metabolic and Mechanical Effects of Laddermill Graded Exercise Testing. J Strength Cond Res 32:195-200
Stanley, Todd H; Van Buiten, Charlene B; Baker, Scott A et al. (2018) Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans. Food Chem 255:414-420
Knott, Eric J; Richard, Allison J; Mynatt, Randall L et al. (2017) Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health. Sci Rep 7:12770
Kim, Youjin; Wu, Alex G; Jaja-Chimedza, Asha et al. (2017) Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice. PLoS One 12:e0184709
Goldsmith, Felicia; Guice, Justin; Page, Ryan et al. (2017) Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat. Mol Nutr Food Res 61:
Jaja-Chimedza, Asha; Graf, Brittany L; Simmler, Charlotte et al. (2017) Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract. PLoS One 12:e0182658

Showing the most recent 10 out of 57 publications