Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA086800-05
Application #
6953624
Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
Project Start
2001-09-01
Project End
2007-08-31
Budget Start
2005-09-27
Budget End
2007-08-31
Support Year
5
Fiscal Year
2005
Total Cost
$58,824
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Dumitrache, Lavinia C; Hu, Lingchuan; Son, Mi Young et al. (2011) Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. Genetics 188:787-97
Dumitrache, Lavinia C; Hu, Lingchuan; Hasty, Paul (2009) TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations. Mutat Res 662:84-7
Trauernicht, Amy M; Kim, Se Jin; Kim, Nam Hee et al. (2007) Modulation of estrogen receptor alpha protein level and survival function by DBC-1. Mol Endocrinol 21:1526-36
Chen, Ming-Jiu; Dumitrache, Lavinia C; Wangsa, Danny et al. (2007) Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells. Cancer Res 67:9077-83
Holcomb, Valerie B; Kim, Tae Moon; Dumitrache, Lavinia C et al. (2007) HPRT minigene generates chimeric transcripts as a by-product of gene targeting. Genesis 45:275-81
Chen, Ming-Jiu; Ma, Sheng-Mei; Dumitrache, Lavinia C et al. (2007) Biochemical and cellular characteristics of the 3'->5'exonuclease TREX2. Nucleic Acids Res 35:2682-94
Marple, Teresa; Kim, Tae Moon; Hasty, Paul (2006) Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination. Mutat Res 602:110-20
Motycka, Teresa A; Bessho, Tadayoshi; Post, Sean M et al. (2004) Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. J Biol Chem 279:13634-9
Marple, Teresa; Li, Han; Hasty, Paul (2004) A genotoxic screen: rapid analysis of cellular dose-response to a wide range of agents that either damage DNA or alter genome maintenance pathways. Mutat Res 554:253-66
Trujillo, Kelly M; Roh, Dong Hyun; Chen, Ling et al. (2003) Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends. J Biol Chem 278:48957-64

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