The objective of this training grant is to teach Postdoctoral Fellows to perform independent research in the area of Radiation Biology, so that they may make significant contributions to the fields of Radiation Oncology and Cancer Biology. This goal will be accomplished using a multi-faceted approach consisting of 1) providing training in the laboratories of outstanding scientists at Vanderbilt University School of Medicine who utilize cutting edge techniques coupled with highly collaborative approaches, 2) course work in the areas of Radiation Biology, Radiation Physics, and Cancer Biology, 3) multi-disciplinary Cancer Center Seminar Series designed to foster interactions between basic scientists and clinician/scientists who perform translational research, and 4) multi-disciplinary departmental seminar series. In addition, trainees will be exposed to clinical oncology environments at Vanderbilt. This program currently supports 3 Postdoctoral trainees, recruiting both M.D.s and Ph.Ds., the majority of which joined our program within 12 months of obtaining their degree. We wish to maintain this level of support. The program is currently funded to support a trainee for up to 3 years, allowing trainees not be well versed in Radiation Biology to become proficient. Training grant preceptors are well qualified to prepare individuals to become outstanding scientists in the field of cancer research, with a focus on radiation biology. They are extremely productive and are outstanding leaders in their respective fields. They are a mix of clinicians/scientists and basic scientists who have joint appointments in clinical and basic science departments at Vanderbilt University and the Vanderbilt-lngram Cancer Center. These preceptors will provide a multi-disciplinary, broad based approach for developing novel paradigms for cancer research. The American Cancer Society estimates that over 700,000 men and 650,000 women will develop cancer in 2005. Approximately 67% of these patients will be treated with ionizing radiation in an attempt to prevent the estimated 500,000 deaths that will occur this year. The purpose of our training program is provide sufficient numbers of highly trained clinicians and scientists who can impact the therapeutic effectiveness of radiation therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA093240-10
Application #
8101151
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2002-07-15
Project End
2012-07-05
Budget Start
2011-07-01
Budget End
2012-07-05
Support Year
10
Fiscal Year
2011
Total Cost
$164,712
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Liu, Xiaojing; Cooper, Daniel E; Cluntun, Ahmad A et al. (2018) Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. Cell 175:502-513.e13
Kusunose, Jiro; Caskey, Charles F (2018) Fast, Low-Frequency Plane-Wave Imaging for Ultrasound Contrast Imaging. Ultrasound Med Biol 44:2131-2142
Traver, Geri; Mont, Stacey; Gius, David et al. (2017) Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung. Free Radic Biol Med 112:578-586
Sorace, Anna G; Syed, Anum K; Barnes, Stephanie L et al. (2017) Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer. Mol Imaging Biol 19:130-137
Feeley, Kyle P; Adams, Clare M; Mitra, Ramkrishna et al. (2017) Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. Cancer Res 77:3823-3833
Mont, Stacey; Davies, Sean S; Roberts Second, L Jackson et al. (2016) Accumulation of isolevuglandin-modified protein in normal and fibrotic lung. Sci Rep 6:24919
Layer, Justin H; Alford, Catherine E; McDonald, W Hayes et al. (2016) LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. Mol Cell Biol 36:488-506
Sorace, Anna G; Quarles, C Chad; Whisenant, Jennifer G et al. (2016) Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results. Breast Cancer Res Treat 155:273-84
Mohni, Kareem N; Thompson, Petria S; Luzwick, Jessica W et al. (2015) A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments. PLoS One 10:e0125482
Carrillo, Alexia M; Hicks, Mellissa; Khabele, Dineo et al. (2015) Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells. Mol Cancer Res 13:1197-205

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