Support is requested to initiate a comprehensive training program in Translational Research in Cancer Genomic Medicine (TRCGM) at the University of California, Irvine. Intensive biomedical research efforts have yielded significant advances in clinical outcomes for a subset of cancers. However, developing useful and effective drugs for treating cancer remains a great challenge. Over the last several years, because of the completion of the human genome, the improved understanding of network connections in cellular regulatory pathways and advance in chemical biology, a plethora of new potential drug targets has been identified through the persistent work in many academic research institutions. These drug targets hold the promise of eventually resulting in the next generation of anti-cancer drugs. UCI has strong programs in basic and clinical cancer research, chemical biology, the development and use of animal models for cancer research. However, until now, no strategy has combined and leveraged these strengths of academic centers in order to train researchers who will be able to integrate basic science with all the aspects of drug development. The 18 proposed faculty were selected as the program faculty for the TRCGM because their research has an important translational component and all are interested in training future translational fellows. The program will focus on training graduate students and postdoctoral and medical fellows in cancer research areas that are highly related to translational research including target identification, chemical biology, preclinical animal models, and clinical trials. Trainees in this program will develop a thorough understanding of the steps required to translate laboratory findings into drugs that may significantly benefit patients in a clinical setting. The NIH has recognized the need for such training in its Roadmap Initiatives. The TRCGM will meet these needs and will train a new cadre of cancer researchers who are able to rapidly and effectively translate laboratory research into medicine, which will improve clinical outcomes by reducing cancer morbidity and mortality.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
Schools of Medicine
United States
Zip Code
Newkirk, Daniel A; Chen, Yen-Yun; Chien, Richard et al. (2017) The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome. Clin Epigenetics 9:89
Sun, Peng; Watanabe, Kazuhide; Fallahi, Magid et al. (2014) Pygo2 regulates ?-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A 111:10215-20
Wang, Dennis Ding-Hwa; Guo, Xuning Emily; Modrek, Aram Sandaldjian et al. (2014) Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. J Biol Chem 289:16727-35
Lee, Briana; Villarreal-Ponce, Alvaro; Fallahi, Magid et al. (2014) Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell 29:47-58
Lee, Briana; Dai, Xing (2013) Transcriptional control of epidermal stem cells. Adv Exp Med Biol 786:157-73
Lee, Briana; Geyfman, Mikhail; Andersen, Bogi et al. (2013) Analysis of gene expression in skin using laser capture microdissection. Methods Mol Biol 989:109-17
Xie, Lifang; Meyskens Jr, Frank L (2013) The pan-Aurora kinase inhibitor, PHA-739358, induces apoptosis and inhibits migration in melanoma cell lines. Melanoma Res 23:102-13
Lin, Li-Fang; Li, Chien-Feng; Wang, Wei-Jan et al. (2013) Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer. PLoS One 8:e73033
Yen, James L; Flick, Karin; Papagiannis, Christie V et al. (2012) Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Mol Cell 48:288-97
Verma, Suman; Salmans, Michael L; Geyfman, Mikhail et al. (2012) The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development. Dev Biol 369:249-60

Showing the most recent 10 out of 29 publications