Breast cancer is the most common cancer among women, accounting for one third of cancer diagnosis in the United States. Eradication of breast cancer is likely to require a partnership of diverse scientific disciplines and training of new breed of basic and translational researchers. The goal of this training grant is to train 6 postdoctoral fellows (including MD and PhD) to perform state-of-the-art research in hormonal regulation, signal transduction, cell cycle controls, cell structure and motility, and experimental therapeutics applied to breast cancer. The strength of the proposed grant is the training faculty. Drawn from both basic science departments and clinical departments (including Braman Family Breast Cancer Institute and Sylvester Comprehensive Cancer Center), the 13 faculty members are an excellent group whose well-funded research comprises a cross-section of structural, molecular and cell biological, basic and translational science approaches to breast cancer research. The faculty members have extensive experience in training graduate students and postdoctoral fellows (including MD/PhD) who have gone onto become successful independent researchers. The overall goal of this program is to provide guidance for trainees to acquire unique research skills and to mold their intellectual rigor to sustain an independent, clinically-informed research career in breast cancer. All trainees are required to attend formal didactic courses, symposia, breast cancer research seminars, grand rounds, workshops, journal clubs and an annual retreat, which provide forum for exchange of ideas and interaction among different disciplines. Progress of the trainee's research will be closely monitored in bi-weekly data reviews. Thus this training program fulfills a serious national need for breast cancer researchers with ample knowledge in basic, clinical and translational research. The proposed program has many unique strengths including : 1) the existence of a specialized breast cancer research institute (Braman Family Breast Cancer Institute) and a well-known cancer center (Sylvester Comprehensive Cancer Center), 2) the research productivity, research funding, training experience, and administrative capability and experience of program faculty in general and the program directors in particular, and 3) the opportunity and availability of infrastructure for fostering continued interactions between clinical and basic research in breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA119929-04
Application #
7918151
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2007-09-19
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
4
Fiscal Year
2010
Total Cost
$285,916
Indirect Cost
Name
University of Miami School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Schuchardt, Brett J; Mikles, David C; Bhat, Vikas et al. (2015) Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch. J Mol Recognit 28:220-31
Mikles, David C; Bhat, Vikas; Schuchardt, Brett J et al. (2015) Effect of osmolytes on the binding of EGR1 transcription factor to DNA. Biopolymers 103:74-87
Mikles, David C; Bhat, Vikas; Schuchardt, Brett J et al. (2014) Enthalpic factors override the polyelectrolyte effect in the binding of EGR1 transcription factor to DNA. J Mol Recognit 27:82-91
Drews-Elger, Katherine; Brinkman, Joeli A; Miller, Philip et al. (2014) Primary breast tumor-derived cellular models: characterization of tumorigenic, metastatic, and cancer-associated fibroblasts in dissociated tumor (DT) cultures. Breast Cancer Res Treat 144:503-17
Mikles, David C; Schuchardt, Brett J; Bhat, Vikas et al. (2014) Role of promoter DNA sequence variations on the binding of EGR1 transcription factor. Arch Biochem Biophys 549:1-11
Schuchardt, Brett J; Mikles, David C; Hoang, Lawrence M et al. (2014) Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity. FEBS J 281:5532-51
Bhat, Vikas; Olenick, Max B; Schuchardt, Brett J et al. (2014) Molecular determinants of the binding specificity of BH3 ligands to BclXL apoptotic repressor. Biopolymers 101:573-82
Schuchardt, Brett J; Bhat, Vikas; Mikles, David C et al. (2014) Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase. Biochimie 101:192-202
Ward, T M; Iorns, E; Liu, X et al. (2013) Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation, and is associated with loss of phosphorylated STAT5. Oncogene 32:2463-74
Mikles, David C; Bhat, Vikas; Schuchardt, Brett J et al. (2013) pH modulates the binding of early growth response protein 1 transcription factor to DNA. FEBS J 280:3669-84

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