This application requests funds to continue the highly successful Radiation Sciences program at the Stanford University School of Medicine, entitled Postdoctoral Training In The Radiation Sciences. This training program meets a crucial need in providing training for the next generation of researchers investigating this critical element of clinical cancer therapy. No other training program at Stanford, and indeed few around the country, addresses the radiation sciences. This program provides our faculty, especially those in non-degree granting departments (e.g., Radiation Oncology and Pathology), the opportunity to recruit and mentor top-notch postdoctoral fellows. The goal of this program is to provide the very best training for its postdoctoral trainees so that they may become successful and independent leaders in the field of radiation and cancer research. The program accomplishes this goal by providing each postdoctoral trainee with a broad and comprehensive curriculum, a vast array of educational resources including seminars, lectures, conferences and workshops specifically geared towards radiation biology, physics, and oncology, a faculty comprised of 16 exceptional preceptors spanning 7 departments with extensive experience in mentoring, and an unparalleled research environment within the Stanford School of Medicine. In addition, postdoctoral trainees audit courses that will aid them in their research and achieving their career goals. Our postdoctoral trainees become independent scientists. They learn to write grants effectively and to obtain their own individual funding. They also learn extensive professional skills such as lab management and mentoring to more successfully compete in today's job market. A key strength of the program is its true multidisciplinary approach to the radiation sciences incorporating such fields as molecular biology, genetics, cell biology, computational biology and bioinformatics, comparative oncology, developmental biology, and tumor biology, as well as biotechnology development for use in cancer diagnosis and therapeutics.
This is a resubmitted application for the T32 postdoctoral training grant in Radiation Sciences at Stanford University. The program has created a thriving and innovative training environment as well as an effective administrative infrastructure, which have been very successful in attracting highly qualified postdoctoral fellows to Stanford University. In this next funding period, we intend to build on this success and to further refine te program to prepare our postdoctoral trainees to become independent and self-reliant scientists, who take positions as junior faculty in academic or research institutions, biotechnology industries, or government laboratories.
|Vilalta, Marta; Brune, Jourdan; Rafat, Marjan et al. (2018) The role of granulocyte macrophage colony stimulating factor (GM-CSF) in radiation-induced tumor cell migration. Clin Exp Metastasis 35:247-254|
|Türkcan, Silvan; Kiru, Louise; Naczynski, Dominik J et al. (2018) Lactic acid accumulation in the tumor microenvironment suppresses 18F-FDG uptake. Cancer Res :|
|Rafat, Marjan; Aguilera, Todd A; Vilalta, Marta et al. (2018) Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Cancer Res 78:4241-4252|
|Ding, Xinxin; Pervere, Leah M; Bascom Jr, Carl et al. (2018) Conditional genetic screen in Physcomitrella patens reveals a novel microtubule depolymerizing-end-tracking protein. PLoS Genet 14:e1007221|
|Castellini, Laura; Moon, Eui Jung; Razorenova, Olga V et al. (2017) KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res 45:3674-3692|
|Zhang, Fan; Flaherty, Patrick (2017) Variational inference for rare variant detection in deep, heterogeneous next-generation sequencing data. BMC Bioinformatics 18:45|
|Acton, Erica; Lee, Amy Huei-Yi; Zhao, Pei Jun et al. (2017) Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress. Open Biol 7:|
|Jeong, Youngtae; Hoang, Ngoc T; Lovejoy, Alexander et al. (2017) Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance. Cancer Discov 7:86-101|
|Aguilera, Todd A; Giaccia, Amato J (2017) Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase. Clin Cancer Res 23:2928-2933|
|Chaudhuri, Aadel A; Chabon, Jacob J; Lovejoy, Alexander F et al. (2017) Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling. Cancer Discov 7:1394-1403|
Showing the most recent 10 out of 56 publications