Abstract

The interface between nanotechnology and medicine is a new frontier for scientific exploration and for the creation of new and improved diagnostic and therapeutic tools to detect, treat, cure, and prevent human diseases. We propose to create a postdoctoral training program in nanotechnology for cancer medicine (NTCM) that will be positioned at this interface and will establish a unique national resource with interdisciplinary and synergistic programs in fundamental research in cancer biology, industrial collaboration, and translational research in cancer medicine. This program will foster postdoctoral fellows who will be trained across disciplines to lay foundations for technologies that will enable an inside-view of cancer cell functions as opposed to the limited black-box input-output techniques currently used, introduce new modalities for molecular imaging, develop new high-throughput diagnostic tools, and engineer novel drug/antibody/siRNA viral and non-viral delivery systems to treat human cancers. NTCM fellows will develop novel cancer diagnostics to evaluate each individual patient's prognosis and optimal treatment, based upon the patients genetic and epi-genetic markers and disease phenotype and therapeutics that are selected and optimized for each individual patient. NTCM trainees will take one of two core courses depending on their background, as well as a lab course in cancer nanobiotechnology. They will also participate in a new journal club and a dedicated annual symposium. The NTCM program will recruit 2 outstanding trainees every year with MD and/or PhD degrees and diverse backgrounds in either biochemistry, physics, molecular/cellular/cancer biology, or an engineering/physics discipline. NTCM fellows will be able to take advantage of research and clinical resources at the NCI-designated Sidney Kimmel Comprehensive Cancer Center, the Ludwick Center for Cancer Genetics and Therapeutics, The Sol Goldman Pancreatic Cancer Center, and the In Vivo Cellular and Molecular Imaging Center, as well as the unique educational resources and experimental facilities of the recently established Johns Hopkins Institute for NanoBioTechnology (INBT). Relevance to Public Health: The proposed postdoctoral training program will train fellows at the interface between nanotechnology and cancer medicine to develop novel nanoscale therapeutic and diagnostic tools for the detection, treatment and cure of human cancer

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA130840-03
Application #
7860637
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2008-07-01
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
3
Fiscal Year
2010
Total Cost
$313,802
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Woodard, Lauren E; Dennis, Cindi L; Borchers, Julie A et al. (2018) Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality. Sci Rep 8:12706
Cheetham, Andrew G; Lin, Yi-An; Lin, Ran et al. (2017) Molecular design and synthesis of self-assembling camptothecin drug amphiphiles. Acta Pharmacol Sin 38:874-884
Binder, Zev A; Wilson, Kelli M; Salmasi, Vafi et al. (2016) Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines. PLoS One 11:e0150271
Norton, Kerri-Ann; Popel, Aleksander S (2016) Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis. Sci Rep 6:36992
Shriver, M; Stroka, K M; Vitolo, M I et al. (2015) Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis. Oncogene 34:4248-59
Mastorakos, Panagiotis; Zhang, Clark; Berry, Sneha et al. (2015) Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain. Adv Healthc Mater 4:1023-33
Salmasi, Vafi; Schiavi, Adam; Binder, Zev A et al. (2015) Intraoperative hypertensive crisis due to a catecholamine-secreting esthesioneuroblastoma. Head Neck 37:E74-80
Schneider, Craig S; Perez, Jimena G; Cheng, Emily et al. (2015) Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells. Biomaterials 42:42-51
Cheetham, A G; Zhang, P; Lin, Y-A et al. (2014) Synthesis and Self-Assembly of a Mikto-Arm Star Dual Drug Amphiphile Containing both Paclitaxel and Camptothecin. J Mater Chem B 2:7316-7326
Lin, Yi-An; Cheetham, Andrew G; Zhang, Pengcheng et al. (2014) Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles. ACS Nano 8:12690-700

Showing the most recent 10 out of 55 publications