This training program seeks to address two issues (1) In spite of all of the research advances in cancer biology and application of these discoveries to the clinic, cancer therapies have had limited success in prolonging life. Engineering approaches have begun to show promise, but there is a dearth of investigators who are trained in both cancer research and engineering/materials science. (2) Current PhD and postdoctoral training in cancer research focuses on preparing trainees to be independent researchers, but it doesn't provide a comprehensive set of skills for young scientists who, when starting their careers in academia, will be working closely with small/startup pharmaceutical or device companies or who may even work in a small firm before reentering academia. There is a synergy in addressing both issues since young scientists with cross training in nanotechnology and cancer biology are well positioned to work in collaboration with or work in small pharmaceutical or medical device companies focused on cancer. The proposed program will provide trainees with a balanced combination of (a) a comprehensive cancer biology, engineering, and entrepreneurship didactic training, (b) laboratory experience dual-mentored by a basic science cancer researcher and clinical/translational cancer faculty, and (c) practical skills learned by having the trainees work with small business entrepreneurs directly and/or prepare and defend research proposals. There will be two training tracks: one for trainees who plan to initially work in startup companies and one for trainees who plan to initially work in academia.

Public Health Relevance

This T32 program will provide predoctoral and postdoctoral scholars with cross training in nanotechnology and cancer biology to position them to work in academia in collaboration with entrepreneurial companies or to start their career directly in small pharmaceutical or medical device companies focused on cancer. The proposed program will provide trainees with a balanced combination of (a) a comprehensive cancer biology, engineering, and entrepreneurship didactic training, (b) laboratory experience dual-mentored by a basic science cancer researcher and clinical/translational cancer faculty, and (c) practical skills learned by having the trainees prepare and defend research proposals and/or work directly with small business entrepreneurs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA153915-09
Application #
9923538
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Lim, Susan E
Project Start
2010-09-03
Project End
2022-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
9
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Pathology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wang, Joanna; Kumeria, Tushar; Bezem, Maria Teresa et al. (2018) Self-Reporting Photoluminescent Porous Silicon Microparticles for Drug Delivery. ACS Appl Mater Interfaces 10:3200-3209
Kumeria, Tushar; Wang, Joanna; Chan, Nicole et al. (2018) Visual Sensor for Sterilization of Polymer Fixtures Using Embedded Mesoporous Silicon Photonic Crystals. ACS Sens 3:143-150
Ward, Erin P; Yang, Jian; Delong, Jonathan C et al. (2018) Identifying lost surgical needles with visible and near infrared fluorescent light emitting microscale coating. Surgery 163:883-888
Wang, James; Barback, Christopher V; Ta, Casey N et al. (2018) Extended Lifetime In Vivo Pulse Stimulated Ultrasound Imaging. IEEE Trans Med Imaging 37:222-229
Wei, Xiaoli; Ying, Man; Dehaini, Diana et al. (2018) Nanoparticle Functionalization with Platelet Membrane Enables Multifactored Biological Targeting and Detection of Atherosclerosis. ACS Nano 12:109-116
Hariri, Ali; Lemaster, Jeanne; Wang, Junxin et al. (2018) The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging. Photoacoustics 9:10-20
Kroll, Ashley V; Fang, Ronnie H; Jiang, Yao et al. (2017) Nanoparticulate Delivery of Cancer Cell Membrane Elicits Multiantigenic Antitumor Immunity. Adv Mater 29:
Kim, Taeho; Lemaster, Jeanne E; Chen, Fang et al. (2017) Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue-Poly(l-lysine) Nanocomplexes. ACS Nano 11:9022-9032