The primary focus of our training program at the University of Kentucky (UK) is to provide intensive and interdisciplinary basic science research training to qualified individuals in the various surgical disciplines to prepare them to become independent scientists and incorporate state-of-the-art techniques learned during their training period into a successful academic career. Moreover, these trainees will be prepared to be active participants in multidisciplinary teams which are required for the optimal treatment of the complex cancer patient. Our two-year training program represents a collaboration between the Markey Cancer Center (MCC) and the academic clinical departments at UK and benefits greatly from the experience and collegiality of the program and associate directors who have worked together for many years and have led other successful training programs for clinician-scientists and basic researchers. The primary training faculty is composed of both basic and clinical-scientists who are collaborative and multidisciplinary; each primary faculty mentor is a recognized expert in his or her field and has a long record of research productivity in the training of young investigators from the US and abroad. The diversity of our training program is further enhanced by the inclusion of seasoned adjunct faculty mentors who will provide additional clinical and biostatistical expertise. Also, we have designed a ?pipeline? mechanism to provide the time and instruction for promising junior faculty members to further hone their mentoring skills so that they can become effective primary mentors in the future. In addition to an intensive research experience, the trainees take formal courses (eg, grant writing skills, ethics and biostatistics) and are mentored in the fine points of preparing abstracts, scientific papers and presentations, and writing successful grant applications. Furthermore, the trainees participate in regularly scheduled MCC, departmental and Center for Clinical and Translational Science (CCTS) seminars and lectures. All of our trainees are required to complete coursework for a Master's degree in Clinical and Translational Science (CTS). In addition, the option of obtaining a PhD is available and encouraged (of note, two former trainees have successfully completed requirements for their PhD degrees and one current trainee is enrolled in the program). The requirement to successfully complete either a Master's or PhD further adds depth and breadth to the program and increase interactions with other scientists on campus through the required supervisory or thesis committees. We are concerned with the alarming decrease in the number of clinician- scientists; this decrease is most apparent in the diminishing number of those in the various surgical specialties. We are passionate, motivated and committed to the training of future academic surgeons.

Public Health Relevance

The number of clinician scientists and, in particular, surgeon scientists is decreasing at an alarming rate; this reduction will negatively impact the ability and rapidity to ?translate? basic discoveries made in cancer research to the patient. Our training program, representing a collaboration between the Markey Cancer Center and the academic clinical departments (Departments of Surgery and Pathology and Laboratory Medicine and the Division of Gynecologic Oncology) at the University of Kentucky, is focused on the interdisciplinary training of future clinician scientists in the various surgical specialties and disciplines. The overall objective of this program is to train clinician scientists in the skills and expertise in basic science and translational research to be competitive in the academic arena and to be active participants in multidisciplinary cancer teams, which are required for the care of the complex cancer patient.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA160003-06A1
Application #
9359571
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Perkins, Susan N
Project Start
2011-07-01
Project End
2022-06-30
Budget Start
2017-07-05
Budget End
2018-06-30
Support Year
6
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Surgery
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40526
Wang, Qingding; Zhou, Yuning; Rychahou, Piotr et al. (2018) Deptor Is a Novel Target of Wnt/?-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth. Cancer Res 78:3163-3175
Frohman, Heather A; Rychahou, Piotr G; Li, Jing et al. (2018) Development of murine bariatric surgery models: lessons learned. J Surg Res 229:302-310
Sun, Ramon C; Fan, Teresa W-M; Deng, Pan et al. (2017) Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nat Commun 8:1646
Vilchez, Valery; Turcios, Lilia; Zaytseva, Yekaterina et al. (2016) Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma. Am J Surg 212:238-45
Stewart, Rachel L; Carpenter, Brittany L; West, Dava S et al. (2016) S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide. Oncotarget 7:34630-42
Stewart, Rachel L; West, Dava; Wang, Chi et al. (2016) Elevated integrin ?6?4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer. Hum Pathol 54:174-83
Li, Jing; Song, Jun; Zaytseva, Yekaterina Y et al. (2016) An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature 533:411-5
Stewart, Rachel L; Dell, Carol M; Samayoa, Luis (2015) Myeloid sarcoma of the breast misdiagnosed as poorly differentiated mammary carcinoma with lobular features. Breast J 21:192-3
Carpenter, Brittany L; Chen, Min; Knifley, Teresa et al. (2015) Integrin ?6?4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF). J Biol Chem 290:27228-38
Zaytseva, Yekaterina Y; Harris, Jennifer W; Mitov, Mihail I et al. (2015) Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. Oncotarget 6:18891-904

Showing the most recent 10 out of 13 publications