This proposal seeks National Cancer Institute (NCI) support for an exciting new Integrative Training in Oncogenic Signaling (ITOS) Program that has been developed by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The ITOS Program takes place in this active and growing medical center environment with state-of-the-art facilities, a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Director with an exceptionally strong cancer research background and leadership experience, the ITOS Program will select and support the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee will have a primary mentor and one or two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that will enhance the overall cancer-related research training experience. The objectives of this training program are to provide proactive mentoring and oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevention, diagnosis, and treatment of cancer. Slated to train five postdoctoral trainees each year for five years, this robust training opportunity has seven programmatic components essential in obtaining the aforementioned objectives. These include the following components: 1) 33 Program Faculty who share common interests in cancer research and will provide the essential mentoring for trainees; 2) one to two year experiences in Program Faculty laboratories found within the vibrant HCC research environment; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries in cancer science; 4) shared research resource workshops and tailored training with experts in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that will equip trainees for independent success; and 7) opportunities to network nationally at a minimum of two professional conferences each year. In summary, the ITOS Program will offer distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to be highly attractive to emerging junior investigators locally and nationally.

Public Health Relevance

Despite the tremendous progress that has been achieved in understanding the complex biology of cancer over the past several decades, it remains a major health care challenge and requires a highly trained workforce to continue to develop new, more effective therapeutic approaches. The Hollings Cancer Center at the Medical University of South Carolina seeks funding for its Integrative Training in Oncogenic Signaling (ITOS) Program. This Program is being led by a specialized group of core scientists who will provide a structured, integrated training experience to ensure the next generation is equipped with contemporary, interdisciplinary approaches and technical expertise that will eventually overcome the challenges to this disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA193201-03
Application #
9516973
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Damico, Mark W
Project Start
2016-07-08
Project End
2021-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Biochemistry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29403
Lv, Zongyang; Williams, Katelyn M; Yuan, Lingmin et al. (2018) Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J Biol Chem 293:18337-18352
Noguchi, Ken; Dincman, Toros A; Dalton, Annamarie C et al. (2018) Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1). J Biol Chem 293:11401-11414
Lv, Zongyang; Yuan, Lingmin; Atkison, James H et al. (2018) Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme. Nat Commun 9:5145
Lv, Zongyang; Yuan, Lingmin; Atkison, James H et al. (2017) Domain alternation and active site remodeling are conserved structural features of ubiquitin E1. J Biol Chem 292:12089-12099
Hua, Yunpeng; Yang, Yi; Sun, Shaoli et al. (2017) Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells. Sci Rep 7:2171
Yuan, Lingmin; Lv, Zongyang; Atkison, James H et al. (2017) Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI. Nat Commun 8:211
Thompson, Ravyn M; Dytfeld, Dominik; Reyes, Leticia et al. (2017) Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells. Oncotarget 8:35863-35876
Noguchi, Ken; Dalton, Annamarie C; Howley, Breege V et al. (2017) Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS One 12:e0177830