This proposal seeks to establish the Carolina Cancer Nanotechnology Training Program (C- CNTP). The goal of the program is to make a major contribution to the growth of the cancer nanotechnology workforce by providing training and research experiences to a highly select cohort of postdoctoral fellows. We have assembled a team of 22 outstanding Program faculty from 11 departments and 3 schools at the University of North Carolina Chapel Hill with specific expertise in physical and material sciences, biomedical engineering, drug delivery, computational modeling as well as basic biomedical research and clinical science, all of whom have demonstrated strong interests, capabilities and collaborations at the interface between nanoscience and cancer. The objectives of the C-CNTP are to: 1) recruit an elite group of talented postdoctoral fellows from diverse backgrounds with PhD or MD and provide them with outstanding postdoctoral experience including focused didactic training and co-mentored research experience with faculty mentors from complementary fields; 2) provide each trainee with Intensive Integrated Learning Accelerating Module training in conjunction with flipped classrooms followed by workshops and didactic courses to remediate differences in their backgrounds and to deepen the knowledge and understanding in the key areas of cancer nanotechnology; and 3) facilitate transition of trainees to independence by providing them with opportunities to a) conduct original cancer nanotechnology research projects; b) apply for the individual cancer nanotechnology Pilot Grants within C-CNTP, and c) acquire written and oral communications skills needed to publish manuscripts, report results, and write successful individual extramural support applications focused on problems of cancer nanotechnology. With the support of the NIH Ruth L. Kirschstein National Research Service Award our institution will establish a world-class postdoctoral training program that will capitalie on the existing strengths in cancer nanotechnology research, consolidate diverse research and education resources across several academic units, and become a significant contributor to addressing the Nation's research needs in cancer nanotechnology.

Public Health Relevance

This multidisciplinary five-year program is designed to train postdoctoral research fellows working at the intersection of nanoscience and cancer research. The goal is to prepare scientists who will successfully pursue careers in academia, industry, and government agencies, and will become significant contributors to addressing emerging challenges in public health and medical research using nanotechnology to diagnose and treat cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA196589-03
Application #
9302324
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Lim, Susan E
Project Start
2015-07-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Pharmacy
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Porrello, Alessandro; Leslie, Patrick L; Harrison, Emily B et al. (2018) Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun 9:1988
Zhang, Maofan; Hagan 4th, C Tilden; Min, Yuangzeng et al. (2018) Nanoparticle co-delivery of wortmannin and cisplatin synergistically enhances chemoradiotherapy and reverses platinum resistance in ovarian cancer models. Biomaterials 169:1-10
Tian, Jing; Min, Yuangzeng; Rodgers, Zachary et al. (2017) Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer. Nanomedicine 13:1301-1307
Hughes, Robert M; Marvin, Christina M; Rodgers, Zachary L et al. (2016) Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents. Angew Chem Int Ed Engl 55:16080-16083
Haney, Matthew J; Zhao, Yuling; Harrison, Emily B et al. (2013) Specific transfection of inflamed brain by macrophages: a new therapeutic strategy for neurodegenerative diseases. PLoS One 8:e61852