We are requesting continued funding of this productive training grant to support pre and postdoctoral fellows in the biomedical aspects of drugs of abuse. The past training record of this program and its preceptors is outstanding. Many of the preceptors in this program have been educating pre and postdoctoral fellows in the field of drugs of abuse for the past thirty years and in some cases more. A large number of individuals who received training from these preceptors are leaders in the drug abuse field and a very impressive number have been received funding from NIDA and other sources for their substance abuse-related research. A considerable number of additional faculty interested in drug abuse research have been recruited to this university since the submission of our last competitive application. We have also been able to attract faculty from within the institution to join the productive large group of scientists who have been working on this program thoughout its existence. The major emphasis of this program continues to be concentrated on the pharmacology and mechanism of action of abused drugs. We continue to have a broad scope in our pharmacological training program and expect that each preceptor in this program will bring their specific expertise to the benefit of each of the trainees. This is accomplished through a wide variety of courses available, the faculty serving on thesis committees and our three excellent seminar series. The program has enjoyed strong support from the Department of Pharmacology and Toxicology throughout its twenty-five years existence and this is ensured for the next funding cycle as Dr. Billy Martin, a leader in this program continues as chair of this department. Dr. Harris, another leader throughout the tenure of this program, continues as Vice Chair. The predoctoral training program is a rigorous graduate program in pharmacology or psychology. The predoctoral program characterized by two years of essential course work with considerable exposure to drug abuse related research. The rest of their training is essentially all research. The major emphasis of all the training supported by this program is research in nature. The faculty have received considerable funding with a healthy mixture of R01, program project, individual career development awards and center grants. The history of collaboration is obvious from their publications. The research projects of the fellows in this program will continue to be directed toward elucidating the abuse potential, the cellular and molecular mechanisms of action and pharmacological properties of drugs of abuse. Postdoctoral fellows will concentrate on research throughout their training. The faculty will provide guidance on research, teaching and the professionalism of biomedical science and all aspects of becoming a productive independent researcher. This has been a hallmark of this program during the past thirty years and will continue to provide the atmosphere for the training of leading scholars in the drug abuse field for the future.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007027-35
Application #
7910554
Study Section
Special Emphasis Panel (ZDA1-MXS-M (08))
Program Officer
Avila, Albert
Project Start
1976-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
35
Fiscal Year
2010
Total Cost
$554,719
Indirect Cost
Name
Virginia Commonwealth University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Donvito, Giulia; Nass, Sara R; Wilkerson, Jenny L et al. (2018) The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology 43:52-79
Wilkerson, Jenny L; Curry, Zachary A; Kinlow, Pamela D et al. (2018) Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain 159:1155-1165
Hill, Rob; Disney, Alex; Conibear, Alex et al. (2018) The novel ?-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception. Br J Pharmacol 175:2653-2661
Kyte, S Lauren; Toma, Wisam; Bagdas, Deniz et al. (2018) Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN. J Pharmacol Exp Ther 364:110-119
Johnson, Amy R; Banks, Matthew L; Selley, Dana E et al. (2018) Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology 43:1753-1762
Hill, Rob; Dewey, William L; Kelly, Eamonn et al. (2018) Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition. Br J Pharmacol 175:2492-2503
Jacob, Joanna C; Sakakibara, Kensuke; Mischel, Ryan A et al. (2018) Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons. Mol Pharmacol 93:417-426
Kyte, S Lauren; Gewirtz, David A (2018) The Influence of Nicotine on Lung Tumor Growth, Cancer Chemotherapy, and Chemotherapy-Induced Peripheral Neuropathy. J Pharmacol Exp Ther 366:303-313
Mischel, Ryan A; Dewey, William L; Akbarali, Hamid I (2018) Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators. iScience 2:193-209
Shin, Myungsun; Snyder, Helena W; Donvito, Giulia et al. (2018) Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo. Mol Pharm 15:721-728

Showing the most recent 10 out of 339 publications