The broad, long term objective of this training program in drug abuse is to prepare a cadre of developing young scientists who will specialize in drug abuse research in their future careers and, thereby, contribute to national research priorities in the biomedical and behavioral neurosciences. The current program will train two predoctoral and two postdoctoral fellows per year in its inaugural 5 year period. The training program will be based within an established PhD program in Cellular and Clinical Neurobiology (CCN) in the Department of Psychiatry and Behavioral Neurosciences at Wayne State University. This program and department have actively recruited a faculty, that specializes in drug abuse research and treatment, and is in a strong position to use this expertise to train pre and postdoctoral fellows in all facets of drug abuse research. All faculty on this training grant serve as faculty in the CCN PhD program, all didactic and research courses are established, a seminar series and Chair's Grand Round are ongoing, and pre-/post-doctoral fellow recruitment and training have matured to the point that a specialized program in drug abuse will integrate seamlessly with current training activities in our department. A comprehensive program of instruction in neurobiology, emphasizing the development of research capabilities in pharmacological, molecular/cellular biological, clinical, and behavioral aspects of substance abuse will lead to the PhD degree for predoctoral trainees. Postdoctoral trainees will be involved in an intensive program of research in the field of drug abuse which will foster the refinement of their investigational skills, and stress further development of their oral and written communication skills. The Program Director will administer this training program with the advice and consent of an Executive Committee. The participating faculty is composed of 16 productive scientists and clinicians, with 8 serving as Training Faculty and 8 serving as Resource Faculty. The combination of an established research training curriculum in neurobiology and a faculty with demonstrated, long-term commitment to the field of drug abuse research, will lead to a cohesive training program specializing in drug abuse, and will produce young scientists who will be among those who dedicate their future careers to the study of drug abuse and addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
1T32DA007310-01A1
Application #
6078880
Study Section
Special Emphasis Panel (ZDA1-KXA-N (21))
Program Officer
Babecki, Beth
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$159,711
Indirect Cost
Name
Wayne State University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Steinmiller, Caren L; Greenwald, Mark (2007) Factors associated with nonmedical use of prescription opioids among heroin-abusing research volunteers. Exp Clin Psychopharmacol 15:492-500
Kuhn, Donald M; Sakowski, Stacey A; Geddes, Timothy J et al. (2007) Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II. J Neurochem 103:1567-73
Sakowski, Stacey A; Geddes, Timothy J; Thomas, David M et al. (2006) Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Res 1085:11-8
Sakowski, Stacey A; Geddes, Timothy J; Kuhn, Donald M (2006) Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. J Neurochem 96:758-65