Long-term goals: Among the current portfolio of NIDA funded training grants, none have comorbidity as a primary focus. This is striking given co-occurrence prevalence of Substance Use Disorders (SUD) with other psychiatric conditions and health conditions (e.g. diabetes), and the extent to which either SUD or the comorbid disorder can go under- or untreated in conventional treatment settings. Enhancing research expertise to improve diagnostic, treatment and prevention strategies is essential. The proposed program will develop a cadre of scientists with research expertise in comorbidity mechanisms, antecedents and correlates, diagnostics, and psychosocial and pharmacological interventions. Component objectives are to provide each trainee with a working knowledge of comorbidity research including: (a) translational science from Early Phase Clinical Trials to Community Based Participatory Research perspectives;(b) effective research strategies for comorbid conditions across populations and ethnic and cultural groups (e.g. American Indian, Hmong, Somali). Accomplishing programmatic features will capitalize on (a) the spectrum of faculty expertise providing mentoring across multiple areas, and (b) integration across training programs and departments. Key Elements: (1) Involvement of scientists and clinicians with diverse expertise and a core internal advisory group. Primary sites (4 postdoctoral trainees, 2 yrs each) are the Departments of Psychiatry (UMN Twin Cities) and Biobehavioral Health &Population Science (UMN Duluth), supported by the Psychology Department (UMTC) and other UMN entities;(2) Recruitment, including under represented group outreach, of rigorously screened PhD and MD candidates with SUD and comorbidity as primary career focus;(3) Training with an interdisciplinary mentoring team (primary &2 secondary mentors) with complementary expertise;(4) Formal training plans with clear milestones including trainee development of an NIH application initiated in Year 1;(5) Active research, seminars, didactic course work, workshops, and development of management, ethics, and regulatory expertise;(6) Dynamic program administration entailing monitoring with enhancements and problem resolution along with continued contact with trainees after completion and;(7) Annually convened external advisory group. Resources: Mentor funding sources include NIH Institutes, NSF, Minnesota Medical Foundation, and pharmaceutical industry. Key Personnel and Primary Mentors are directors of clinics, centers, or departments with significant resources. The program focuses on trainee expertise in SUD co-occurring with psychiatric disorders (Anxiety, ADHD, Borderline, Eating, Depression, Schizophrenia, Trauma).

Public Health Relevance

Substance use disorders (e.g. alcohol, opioids, cocaine, nicotine) are commonly associated with other psychiatric conditions (e.g. depression, schizophrenia). The disorder combinations are not well understood and are often under-treated or untreated. The problems may be exacerbated, or treatment efficacy attenuated, by individual, ethnic and cultural factors. There is a need to train researchers expert in examining determinants and developing effective prevention and treatment strategies for the combined problems and circumstances;this is the focus of the post doctoral training program.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDA1)
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Onken, Lisa
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Venables, Noah C; Foell, Jens; Yancey, James R et al. (2018) Integrating Criminological and Mental Health Perspectives on Low Self-Control: A Multi-Domain Analysis. J Crim Justice 56:2-10
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Longenecker, Julia M; Venables, Noah C; Kang, Seung Suk et al. (2018) Brain Responses at Encoding Predict Limited Verbal Memory Retrieval by Persons with Schizophrenia. Arch Clin Neuropsychol 33:477-490
Hautala, Dane; Sittner, Kelley (2018) Moderators of the Association Between Exposure to Violence in Community, Family, and Dating Contexts and Substance Use Disorder Risk Among North American Indigenous Adolescents. J Interpers Violence :886260518792255
Forbes, Miriam K; Kotov, Roman; Ruggero, Camilo J et al. (2017) Delineating the joint hierarchical structure of clinical and personality disorders in an outpatient psychiatric sample. Compr Psychiatry 79:19-30
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Forbes, Miriam K; Rapee, Ronald M; Camberis, Anna-Lisa et al. (2017) Unique Associations between Childhood Temperament Characteristics and Subsequent Psychopathology Symptom Trajectories from Childhood to Early Adolescence. J Abnorm Child Psychol 45:1221-1233
Greenfield, Brenna L; Sittner, Kelley J; Forbes, Miriam K et al. (2017) Conduct Disorder and Alcohol Use Disorder Trajectories, Predictors, and Outcomes for Indigenous Youth. J Am Acad Child Adolesc Psychiatry 56:133-139.e1
Forbes, Miriam K; Eaton, Nicholas R; Krueger, Robert F (2017) Sexual Quality of Life and Aging: A Prospective Study of a Nationally Representative Sample. J Sex Res 54:137-148
Venables, Noah C (2017) Reward Mechanisms Across Aggressive and Addictive Forms of Externalizing Psychopathology. Biol Psychiatry 82:e25-e27

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