? This application is a competing renewal application for years 32-37 for this Training Grant in Diabetes and Endocrinology. It was the first, and remains the longest-running, T-32 grant at the University of Pittsburgh School of Medicine. The goals of the application are: ? A. To attact outstanding MD and PhD postdoctoral trainees with authentic academic interests and potential. ? B. To pair them with similarly outstanding research training faculty to serve as mentors. ? C. To provide a venue for outstanding training and mentoring in diabetes, obesity, bone and mineral, osteoporosis and cellular and molecular endocrinology research. ? D. To eliminate the barriers between clinical, basic and translational research in Endocrinology. ? E. To support the trainee's and mentor's needs in providing this outstanding training. ? F. To provide a supportive and highly enriching didactic environment in which to receive this training. ? G. To help the trainees transition to junior faculty positions. ? H. To protect trainees from clinical responsibilities while receiving research training. ? I. To provide opportunities for research training to all members of all ethnic groups. ? J. To provide instruction in research integrity. ? In the last round of funding, the program has shown a strong record of meeting all of these goals, with 8 of 13 graduates in the past 10 years now serving in academic positions, and one in a research position in pharmacology ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007052-35S1
Application #
7661859
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
1975-07-01
Project End
2010-06-30
Budget Start
2008-08-01
Budget End
2009-06-30
Support Year
35
Fiscal Year
2008
Total Cost
$61,557
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kim, Joon Young; Tfayli, Hala; Michaliszyn, Sara F et al. (2018) Impaired Lipolysis, Diminished Fat Oxidation, and Metabolic Inflexibility in Obese Girls With Polycystic Ovary Syndrome. J Clin Endocrinol Metab 103:546-554
Frahm, Krystle A; Waldman, Jacob K; Luthra, Soumya et al. (2018) A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol 471:42-50
Corbit, Kevin C; Camporez, João Paulo G; Edmunds, Lia R et al. (2018) Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes 67:208-221
Xiong, Jianhua; Kawagishi, Hiroyuki; Yan, Ye et al. (2018) A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Mol Cell 69:689-698.e7
Kim, Joon Young; Nasr, Alexis; Tfayli, Hala et al. (2017) Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired ?-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance. Diabetes 66:3085-3090
Howlett, Evan H; Jensen, Nicholas; Belmonte, Frances et al. (2017) LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease. Hum Mol Genet 26:4340-4351
Costa, Diana K; Huckestein, Brydie R; Edmunds, Lia R et al. (2016) Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. Am J Physiol Endocrinol Metab 311:E105-16
Wang, Huabo; Lu, Jie; Edmunds, Lia R et al. (2016) Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem 291:26241-26251
Bannwarth, Sylvie; Berg-Alonso, Laetitia; Augé, Gaëlle et al. (2016) Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice. Mitochondrion 30:126-37
Belmonte, Frances R; Martin, James L; Frescura, Kristin et al. (2016) Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions. Sci Rep 6:25186

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