The Diabetes and Hormone Action Training program at the University of Virginia promotes the academic development of basic and clinical scientists who will focus their research efforts in the area of diabetes and related disorders Diabetes is a prevalent, serious, metabolic disorder that affects more than 16 million Americans As alarming, the prevalence of impaired glucose tolerance or """"""""pre-diabetes"""""""" affects a similar number of individuals In addition, the age of diagnosis for people with diabetes is moving to progressively younger individuals in the population For the country to successfully cope with the now recognized epidemic increase in diabetes, pre- diabetes, and the """"""""insulin-resistance"""""""" syndrome will require an expanded, talented, well-trained cohort of clinical and basic scientists These individuals must be equipped with a broad understanding of the diverse complications of diabetes, as well as the diverse causes for diabetes and insulin resistance The environment of the University of Virginia's Diabetes Center is well-suited as a focal center for training program in diabetes and hormone action The Center is interdepartmental, reporting directly to the Dean of the School of Medicine It contains considerable research resources in the form of laboratory space, well-equipped core laboratories, and an expanded complement of both junior and senior investigators involved in both clinical and basic research related to diabetes The training programs major strength is this outstanding group of program faculty with established national and international reputations in the area of diabetes, hormone action, cell signaling, islet cell function, and clinical investigation The center runs its own seminar program This is an intellectual focal point and affords trainees the opportunity to meet with distinguished scientists from many institutions and to present their own research projects Most importantly, the Center is a highly interactive community of scientists who collaborate on projects that impact on many areas of diabetes, hormone action, and cellular signaling The training program has been in operation for 24 years During that time over 80 fellows have been trained Acceptance into the program is decided by the Training Grant Advisory Committee Over the entire duration of the program approximately 45 percent of trainees are M D s and 55 percent Ph D graduates Most currently hold positions as investigators at academic institutions and in the biomedical research industry throughout the United States Training is focused on specific projects in laboratory of the mentoring investigators and individualized to specific needs and career goals of the trainee The training occurs in an interdisciplinary atmosphere, often involving collaborative input from both clinical and basic scientists The atmosphere of interdepartmental and interdisciplinary cooperation with a focus on a complex disease such as diabetes is well-suited to training bright, creative future investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007320-28
Application #
6929709
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
1978-09-15
Project End
2008-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
28
Fiscal Year
2005
Total Cost
$219,559
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Warthen, Daniel M; Lambeth, Philip S; Ottolini, Matteo et al. (2016) Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake. Front Behav Neurosci 10:63
Subaran, Sharmila C; Sauder, Matthew A; Chai, Weidong et al. (2014) GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. Clin Sci (Lond) 127:163-70
Upchurch, Charles T; Barrett, Eugene J (2012) Clinical review: Screening for coronary artery disease in type 2 diabetes. J Clin Endocrinol Metab 97:1434-42
Majumdar, S; Genders, A J; Inyard, A C et al. (2012) Insulin entry into muscle involves a saturable process in the vascular endothelium. Diabetologia 55:450-6
Kashmer, Laurissa; Clarke, William; Gurka, Matthew et al. (2009) Predictors of parental interest in continuous glucose monitoring for children with type 1 diabetes. Diabetes Technol Ther 11:373-8
Davies, Lucinda A; Hu, Changlong; Guagliardo, Nick A et al. (2008) TASK channel deletion in mice causes primary hyperaldosteronism. Proc Natl Acad Sci U S A 105:2203-8
McDuffie, Marcia; Maybee, Nelly A; Keller, Susanna R et al. (2008) Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes 57:199-208
Wang, Hong; Liu, Zhenqi; Li, Guolian et al. (2006) The vascular endothelial cell mediates insulin transport into skeletal muscle. Am J Physiol Endocrinol Metab 291:E323-32
Francis, Joshua; Babu, Daniella A; Deering, Tye G et al. (2006) Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1. Mol Endocrinol 20:3133-45
Iype, Tessy; Taylor, David G; Ziesmann, Suzanne M et al. (2004) The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Mol Endocrinol 18:1363-75

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