The institutional NRSA program sponsored by the Diabetes & Metabolic Diseases Research Center (DMDRC) offers multidisciplinary post-graduate training opportunities to the scientifically-trained (Ph.D.) and clinically-trained (M.D.) to acquire expertise in the study of metabolic diseases using state-of-the-art approaches of biochemistry, cell and molecular biology. Opportunities for training include diabetes & insulin action, protein metabolism, G-protein-coupled receptor action in disease states, cell signaling, Ras and MAP kinase regulation. Expertise is derived from 27 trainers from 9 departments with basic/clinical research in 5 major disciplines (physiology, pharmacology, biochemistry, molecular biology & cell biology). The training faculty support the tenet that a successful research career in the diverse and multifaceted area of endocrine and metabolic diseases requires a broadly-based background founded in these five major disciplines as well as a hybrid perspective which is receptive to strategies transcending the limits of one's immediate specialty. Training is principally as participants in vigorous, supportive research programs of individual trainers as well as more-broadly-based training as DMDRC members. Trainees actively participate in weekly interdepartmental seminars, minisymposia, journal clubs in specialized areas (endocrinology, cell signaling), and periodic scientific meetings where reports on original research are presented. The trainees (8 per year) will be principally medical (M.D.) or Ph.D. graduates who demonstrate a keen interest in taking advantage of these opportunities. Emphasis is placed on the vigorous recruitment of women and underrepresented minorities. Trainees are selected based upon their ability to conduct original research in a careful and critical manner, the nature and quality of their thesis and/or prior work, and recommendations by referees. Competitive applicants visit the campus and present a seminar. Facilities include modem laboratories (>80,000 n.s.f.) equipped for original research endeavors. Unique opportunities exist for advanced training in transgenic and KO mice use, molecular biology, proteomics (MALDI and QToF mass spectrometry) & structural biology, microscopy & imaging analysis, DNA microarray, and iRNA use. The DMDRC T32 program sponsors bioethics training, career building, and planning. The DMDRC training program enjoys strong University-wide support.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
State University New York Stony Brook
Schools of Medicine
Stony Brook
United States
Zip Code
Rist, Pamela M; Jiménez, Monik C; Tworoger, Shelley S et al. (2018) Plasma Retinol-Binding Protein 4 Levels and the Risk of Ischemic Stroke among Women. J Stroke Cerebrovasc Dis 27:68-75
Gillis, William Q; Kirmizitas, Arif; Iwasaki, Yasuno et al. (2016) Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. Cell Commun Signal 14:15
Ambrosi, Christina M; Boyle, Patrick M; Chen, Kay et al. (2015) Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability. Sci Rep 5:17350
Kirmizitas, Arif; Gillis, William Q; Zhu, Haitao et al. (2014) Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos. Dev Biol 392:358-67
Ambrosi, Christina M; Klimas, Aleksandra; Yu, Jinzhu et al. (2014) Cardiac applications of optogenetics. Prog Biophys Mol Biol 115:294-304
Yallowitz, A R; Alexandrova, E M; Talos, F et al. (2014) p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis. Cell Death Differ 21:645-54
Ambrosi, Christina M; Entcheva, Emilia (2014) Optogenetic control of cardiomyocytes via viral delivery. Methods Mol Biol 1181:215-28
Williams, John C; Xu, Jianjin; Lu, Zhongju et al. (2013) Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model. PLoS Comput Biol 9:e1003220
Bossert, Patricia E; Dunn, Matthew P; Thomsen, Gerald H (2013) A staging system for the regeneration of a polyp from the aboral physa of the anthozoan Cnidarian Nematostella vectensis. Dev Dyn 242:1320-31
Alexandrova, Evguenia M; Moll, Ute M (2012) Role of p53 family members p73 and p63 in human hematological malignancies. Leuk Lymphoma 53:2116-29

Showing the most recent 10 out of 69 publications