EXCEED THE SPACE PROVIDED. A uniqueprogram is proposed to train pre- and postdoctoral PhD fellows for research careers in the pathobiology, particularly involvingdigestive diseases, and to provide physicians within-depth interdisciplinary training in modem biology as related to digestive disease pathobiology. Physicians spend three years in individualized research training, courses and laboratory rotations related to specific interests under supervision of an advisory committee. Training is supervised by 19 experienced preceptors associated with the Departments of Physiology-Pathophysiology, Medicine, Microbiology and GRASP (NIDDK - Center) at Tufts UniversitySchool of Medicine. Faculty are basic scientists and basically-oriented physician scientists who share enthusiasm for the proposed novel program and who have substantialresearch records and support in areas related to digestive diseases. The major research goal is to understandhow events on the surface of cells (i.e., pumps,channels, receptors, etc.) control gene expression as related to signal transduction, regeneration, differentiation and polarity under physiologic conditionsand in disease states. The program includesseminars, journal club and graduate courses includinga unique program in Pathobiology for PhD Students and Fellows. Our goal is to bridge the gap between major advances in biology and their application to human digestive diseases. We seek to train PhD graduates and physicianswho will work independentlywith clinicalinvestigators rather thanfor them. The major goal is to reduce the intellectual barriers which separate basic scientists from their clinical colleagues and thereby enhance the transfer of knowledge from one discipline to another. PERFORMANCE SITE ========================================Section End===========================================
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