The Research Training Program is intended to equip Ph.D. scientists and select physicians at the postdoctoral level for independent research careers in the field of Urology. The program is based on the research interests and expertise of 20 faculty members in the Department of Urology, the Department of Human Genetics, the Department of Pediatrics, the Department of Pathology, the Department of Geriatrics, School of Dentistry, School of Public Health and the Department of Internal Medicine. General areas of research focus include (1) the molecular basis of neoplastic transformation, (2) signal transduction pathways, (3) the development of novel immunologic and gene therapy approaches to the treatment of urologic cancers, (4) the development of novel methods for urinary tract reconstruction, (5) apoptosis, (6) mechanisms of cell cycle control, (7) androgen receptor control, (8) the biology of prostate cancer metastasis, and (9) the epidemiology of prostatic disease. Trainees selected for this program spend two years in the laboratory under the direct supervision of a training program faculty mentor and develop skills in (1) identifying testable hypotheses that address important questions in urology research, (2) acquiring the necessary technical expertise to test the hypotheses identified, (3) critically evaluating the data generated, and (4) developing the necessary written and oral communication skills to promulgate the conclusions made. Trainees have a PhD or MD degree with the intention of pursuing a career in a field relevant to the Urologic Sciences. M.D. trainees with limited prior research experience participate in an intensive 3 month Post-Doctoral Research Training Program to introduce important concepts in cellular and molecular biology. During their research training experience, trainees are expected to attend relevant research and clinical conferences and to present the results of their research efforts in laboratory meetings and research conferences. Trainees are expected to apply for individual extramural research support, and to author research reports and abstracts for publication and presentation. The progress of trainees is monitored continuously by their research mentors and yearly by the Administrative Committee. Upon completion of the post-doctoral training period, trainees are prepared to pursue independent academic careers in urology.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Moen, Laura K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
McDowell, Kristy L; Begley, Lesa A; Mor-Vaknin, Nirit et al. (2010) Leukocytic promotion of prostate cellular proliferation. Prostate 70:377-89
Yocum, Anastasia K; Chinnaiyan, Arul M (2009) Current affairs in quantitative targeted proteomics: multiple reaction monitoring-mass spectrometry. Brief Funct Genomic Proteomic 8:145-57
Frohlich, D A; McCabe, M T; Arnold, R S et al. (2008) The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis. Oncogene 27:4353-62
Hollingsworth, John M; Hollenbeck, Brent K; Englesbe, Michael J et al. (2007) Operative mortality after renal transplantation--does surgeon type matter? J Urol 177:2255-9;discussion 2259
Hollingsworth, John M; Miller, David C; Daignault, Stephanie et al. (2007) Five-year survival after surgical treatment for kidney cancer: a population-based competing risk analysis. Cancer 109:1763-8
Hollingsworth, John M; Miller, David C; Daignault, Stephanie et al. (2007) Variable penetrance of a consensus classification scheme for renal cell carcinoma. Urology 69:452-6
Hollingsworth, John M; Krein, Sarah L; Miller, David C et al. (2007) Payer leverage and hospital compliance with a benchmark: a population-based observational study. BMC Health Serv Res 7:112
Hall, Christopher L; Dai, JinLu; van Golen, Kenneth L et al. (2006) Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone. Cancer Res 66:8648-54
Hollingsworth, John M; Miller, David C; Daignault, Stephanie et al. (2006) Rising incidence of small renal masses: a need to reassess treatment effect. J Natl Cancer Inst 98:1331-4
Hollingsworth, John M; Rogers, Mary A M; Kaufman, Samuel R et al. (2006) Medical therapy to facilitate urinary stone passage: a meta-analysis. Lancet 368:1171-9

Showing the most recent 10 out of 13 publications