EXCEED THE SPACE PROVIDED. Yale University School of Medicine is seeking to be one of the centers of excellence in diabetes training that will allow bright young pediatricians to establish academic careers in pediatric endocrinology as independent investigators in diabetes. In this T32 application, we are requesting 2 post-doctoral fellowship stipends per year for 5 years. Yale has an impressive array of resources that will support this program, including a DERC, separate Children and Adult GCRC's, JDRF Center for the Study of Hypoglycemia, Pediatric Pharmacology Research Unit, Child Health Research Center, Mouse Metabolic Phenotyping Center, NMR Center and a new 450,000 sq. foot clinical science research facility. The Program Director and training faculty are highly respected and productive investigators with extensive peer-reviewed grant support to fund trainees' projects. Our faculty has a long history of extensive collaborations and an outstanding track record in training post-doctoral fellows. Post-doctoral trainees can choose between five major areas of research training (pathophysiology of T1 and T2 DM, hypoglycemia/neurobiology, immunobiology of diabetes and behavioral/psychosocial aspects of diabetes) and 4-6 primary and secondary mentors within each area. A centerpiece of our educational activities is the Investigative Medicine Program that provides a rigorous curriculum of required and elective courses along two pathways, i.e. patient-oriented and disease-oriented. Successful completion of course work and thesis project will allow trainees to receive a Ph.D. that is awarded through the Department of Medicine. Alternative curricula for non-Ph.D, candidates include the Quantitative Clinical Epidemiology Icourse offered by the Robert Wood Johnson Clinical Scholars Program and the Seminar Series for Young Investigators offered by the Yale Child Health Research Center. The formation of a 'consortium' of three centers of excellence in diabetes research training will allow us to collaborate in training efforts as well as in innovative recruitment plans. Moreover, Dr. James Gavin, former President of the ADA and incoming President of Morehouse School of Medicine, has indicated his interest in linking his school to our program in the recruitment of African American trainees. PERFORMANCE SITE ========================================Section End===========================================

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-B (O2))
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Medicine
New Haven
United States
Zip Code
Sherr, Jennifer L; Ghazi, Tara; Wurtz, Anna et al. (2014) Characterization of residual ? cell function in long-standing type 1 diabetes. Diabetes Metab Res Rev 30:154-62
Jastreboff, Ania M; Sinha, Rajita; Lacadie, Cheryl et al. (2013) Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels. Diabetes Care 36:394-402
Palau-Collazo, Miladys M; Rose, Paulina; Sikes, Kristin et al. (2013) Effectiveness of a spanish language clinic for Hispanic youth with type 1 diabetes. Endocr Pract 19:800-4
Jastreboff, Ania M; Potenza, Marc N; Lacadie, Cheryl et al. (2011) Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: an FMRI study. Neuropsychopharmacology 36:627-37
Sherr, Jennifer; Tamborlane, William V (2008) Past, present, and future of insulin pump therapy: better shot at diabetes control. Mt Sinai J Med 75:352-61
Huo, Betty; Steffen, Amy T; Swan, Karena et al. (2007) Clinical outcomes and cost-effectiveness of retinopathy screening in youth with type 1 diabetes. Diabetes Care 30:362-3