The Pediatric Nephrology Training Program at the University of Michigan is designed to recruit the best post- doctoral trainees and prepare them for a career in Basic, Epidemiology/Outcomes or Clinical Research. Training will be carefully designed and individually tailored for each trainee and will combine a didactic program with a mentored research experience. The proposed Training Program will provide 2 or more years of postdoctoral research training in Nephrology to MD trainees in 2 areas: a) Basic Laboratory Research; and b) Clinical Investigation and Epidemiology research. Ph.D. trainees will receive intensive basic laboratory training in a lab performing pediatric nephrology/developmental research. Four trainees will be appointed yearly. The Training Program will be provided by 42 faculty members from 8 departments and 3 schools/colleges, all of whom have substantial training experience. Given the considerable scientific collaboration among the various members of the Program Faculty, there will be ample opportunity for a given trainee to gain research experience in more than one research setting during his or her training experience. The majority of trainees will enroll in intensive didactic programs depending on their research track. Those in the basic science track will complete a three month Postgraduate Research Training Program. Those in the clinical investigation and epidemiology research track will typically complete a Masters of Public Health program in Biostatistics and Epidemiology or a Masters of Science program in the Clinical Research Design and Statistical Analysis course. Weekly seminar series conducted by the Training Program will complement the formal curricula. Mentored research will be supported by the resources of the Medical School, the Department of Pediatrics, The Division of Pediatric Nephrology, the Division of Nephrology, the individual faculty members, and by the George M. O'Brien Renal Center (for basic research), the Kidney Epidemiology and Cost Center (for epidemiology/outcomes research), and Arbor Research (for clinical or epidemiology/outcomes research). All trainees will be required to submit individual fellowship or grant applications and abstracts for national meetings during their training. Based on this training and the excellent track record of graduates from the Training Program in Nephrology, fellows will be well positioned for independent careers in Pediatric Nephrology research.

Public Health Relevance

Pediatric Nephrology has faced ongoing physician shortages and has one of the oldest workforces of any Pediatric subspecialty. This contributes to a higher percentage of children than adults starting dialysis without prior nephrologist care and a lack of improvement in patient outcomes. In the 2007 Annual Data Report of the United States Renal Data System the need to """"""""focus on developing new approaches in treating this most vulnerable population"""""""" was cited. Our trainees will develop and implement new diagnostic and therapeutic strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK065517-10
Application #
8513978
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
2004-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$204,190
Indirect Cost
$14,275
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wickman, Larysa; Afshinnia, Farsad; Wang, Su Q et al. (2013) Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases. J Am Soc Nephrol 24:2081-95
Tanzer, Marie; Tran, Cheryl; Messer, Kassandra L et al. (2013) Inpatient health care utilization by children and adolescents with systemic lupus erythematosus and kidney involvement. Arthritis Care Res (Hoboken) 65:382-90
Tran, Cheryl L; Ehrmann, Brett J; Messer, Kassandra L et al. (2012) Recent trends in healthcare utilization among children and adolescents with hypertension in the United States. Hypertension 60:296-302
Lombel, Rebecca M; Kommareddi, Mallika; Mottes, Theresa et al. (2012) Implications of different fluid overload definitions in pediatric stem cell transplant patients requiring continuous renal replacement therapy. Intensive Care Med 38:663-9
Yallowitz, Alisha R; Hrycaj, Steven M; Short, Kieran M et al. (2011) Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS One 6:e23410
Selewski, David T; Cornell, Timothy T; Lombel, Rebecca M et al. (2011) Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy. Intensive Care Med 37:1166-73
Blatt, Neal B; Boitano, Anthony E; Lyssiotis, Costas A et al. (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem Pharmacol 78:966-73
Blatt, Neal B; Boitano, Anthony E; Lyssiotis, Costas A et al. (2008) Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radic Biol Med 45:1232-42