The Department of Urology at the University of Florida has trained many outstanding academic urologists for more than fifty years. The current proposal is dedicated to establishing a new and transformational effort to educate both MD and PhD trainees through an intense laboratory or clinical investigation-based educational program designed to provide them with the essential intellectual foundation to become successful independently-funded investigators. For clinical investigators, formal didactic training through CTSI in epidemiology, biostatistics, clinical trials design, critical appraisal of medical literatue, and data base management form the basis of the training agenda. For PhDs, the building of bridges to basic science and the development of interdisciplinary translational research teams is a major focus. This program comprises more than twenty exceptional training faculty falling into four thematically-related scientific groups focused on problems pertinent to the field of urology. These groups are urolithiasis and metabolic disorders (Drs. Khan, Benjamin Canales, Brown, Weiner, Limacher), stem cells and regenerative medicine (Drs. Steindler, Scott, Reynolds, Terada) immunology/inflammation (Drs. Clare-Salzler, Vieweg, Moldawer, Chegini), functional genomics and cell signaling (Drs. Johnson, Daaka, Wood, Conrad, Stacpoole, Nie, Shenkman). In addition to these preceptors, clinical advisors will assist with mentoring and day-to-day functioning of the training grant program (Drs. Su, Muna Canales, Bird, Gilbert, Dahm, Moy, Yeung, Stringer). As will be demonstrated, considerable interaction and collaboration already exists between the members of this training grant faculty and all have distinguished records as educators and NIH-funded investigators. We have successfully created a superb environment for high quality education in the basic, applied and clinical sciences relevant to the study of urologic diseases for both the MD and PhD trainee at the University of Florida.

Public Health Relevance

Urologic diseases impact millions of Americans on an annual basis and leads to significant morbidity and mortality. This new T32 Training Grant will develop a new cadre of well-trained, academic urologists who through translational research will improve our understanding and treatment of non-cancerous urologic disorders.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Rankin, Tracy L
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University of Florida
Internal Medicine/Medicine
Schools of Medicine
United States
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O'Kell, Allison L; Lovett, Archana C; Canales, Benjamin K et al. (2018) Development of a two-stage model system to investigate the mineralization mechanisms involved in idiopathic stone formation: stage 2 in vivo studies of stone growth on biomimetic Randall's plaque. Urolithiasis :
Dominguez-Gutierrez, Paul R; Kusmartsev, Sergei; Canales, Benjamin K et al. (2018) Calcium Oxalate Differentiates Human Monocytes Into Inflammatory M1 Macrophages. Front Immunol 9:1863
O'Kell, Allison L; Garrett, Timothy J; Wasserfall, Clive et al. (2017) Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes. Sci Rep 7:9467
O'Kell, Allison L; Wasserfall, Clive; Catchpole, Brian et al. (2017) Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? Diabetes 66:1443-1452
Bird, Victoria Y; Chastain-Gross, Ryan; Sutkowski, Raymond et al. (2017) Pseudomonas aeruginosa as an Etiologic Agent of Nephrolithiasis in Deep Water Divers. J Endourol Case Rep 3:4-6
O'Kell, Allison L; Grant, David C; Khan, Saeed R (2017) Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats. Urolithiasis 45:329-336
Kusmartsev, Sergei; Dominguez-Gutierrez, Paul R; Canales, Benjamin K et al. (2016) Calcium Oxalate Stone Fragment and Crystal Phagocytosis by Human Macrophages. J Urol 195:1143-51