The burden of diabetes and its complications stresses the need for academic research institutions and diabetes researchers to train well-qualified research scientists to develop new avenues for the treatment, prevention and cure of diabetes. The primary goal of this training grant is to train PhD basic scientists for careers in diabetes research using a multidisciplinary and comprehensive learning experience, scientific interactions and mentorship to develop a deep understanding of the molecular aspects of diabetes. This training program is embedded within the rich research environment of the University of Michigan, which includes a highly collegial, and interdisciplinary diabetes research community and excellent core resources for biomedical research. The training program builds on the unique expertise of the group of preceptors in different components of the pathogenesis diabetes and its complications. Training grant preceptors fall into six major interest groups - islt biology, autoimmune diabetes, adipocyte biology, hypothalamic regulation of metabolism, mechanisms of Insulin resistance and metabolic control (liver, adipocyte and muscle groups) and diabetes complications. The program includes training in the individual laboratory but is supplemented by a core curriculum in molecular pathogenesis of diabetes as well as an interdisciplinary and collaborative series of educational project meetings, seminars, activities in grant writing, career advance and research methodologies. This training will provide the necessary tools for transition to independence. This program includes 18 mentors in a highly collaborative environment with stable extramural funding who have appointments in nine separate departments in the School of Medicine and two Divisions within the Department of Internal Medicine. This program will provide a significant complement for the training mission of the Michigan Diabetes Research Center and the Nutrition and Obesity Research Center. The training program will be administered through the Division of Metabolism Endocrinology and Diabetes, and will be overseen by an executive committee comprising the Principal Investigator, one co-director and four members of whom are senior investigators with strong mentoring track records.

Public Health Relevance

Our program offers training experiences designed to educate basic scientists using a multidisciplinary and comprehensive learning and mentorship that develops a deep understanding of the molecular aspects of diabetes. Training is a combination of immersion in specific research projects under the direction of experienced and accomplished senior researchers, formal education, and participation in a variety of other research related educational activities. This training program will fill a critical need to increase the number of future leaders in diabetes research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK101357-02
Application #
8917212
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2014-09-01
Project End
2019-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
2
Fiscal Year
2015
Total Cost
$236,572
Indirect Cost
$17,524
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Muir, Lindsey A; Kiridena, Samadhi; Griffin, Cameron et al. (2018) Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages. J Leukoc Biol 103:615-628
Hinder, Lucy M; Murdock, Benjamin J; Park, Meeyoung et al. (2018) Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story. Exp Neurol 305:33-43
Peck, Bailey C E; Seeley, Randy J (2018) How does 'metabolic surgery' work its magic? New evidence for gut microbiota. Curr Opin Endocrinol Diabetes Obes 25:81-86
Adams, Jessica M; Pei, Hongjuan; Sandoval, Darleen A et al. (2018) Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes 67:1538-1548
Allison, Margaret B; Pan, Warren; MacKenzie, Alexander et al. (2018) Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action. Diabetes 67:1093-1104
Rumora, Amy E; Lentz, Stephen I; Hinder, Lucy M et al. (2018) Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons. FASEB J 32:195-207
Baker, Nicki A; Muir, Lindsey A; Washabaugh, Alexandra R et al. (2017) Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix. J Clin Endocrinol Metab 102:1032-1043
Muir, Lindsey A; Baker, Nicki A; Washabaugh, Alexandra R et al. (2017) Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery. Adipocyte 6:134-140
Baker, Nicki A; Muir, Lindsey A; Lumeng, Carey N et al. (2017) Differentiation and Metabolic Interrogation of Human Adipocytes. Methods Mol Biol 1566:61-76
Hinder, Lucy M; Park, Meeyoung; Rumora, Amy E et al. (2017) Comparative RNA-Seq transcriptome analyses reveal distinct metabolic pathways in diabetic nerve and kidney disease. J Cell Mol Med 21:2140-2152

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