The goal of our proposed plan is to renew and improve a highly successful 10 year training program to develop in clinician scientists the ability to employ imaging techniques to the investigation of medical disorders in a wide spectrum of medical disciplines. The proposed program will continue to correct the current dearth of clinicians who are able to utilize the state-of-the-art tools available to enhance imaging for applications in radiology and other specialties. The proposed program will increase the ongoing participation of trainees and mentors in radiology and nuclear medicine, as well as internal medicine, neurology, neuropathology, oncology, pediatrics, psychiatry, and surgery, with future trainees and mentors from anatomical pathology, orthopedics, and urology in this renewal. The prior 5 years were funded by NIBIB (primary), NIDA, NIDDK, and NIAAA, and will now be expanded by NIA and NIMH, for a total of 6 slots per year for 5 additional years. The current and future program will provide training in structured rigorous research for non-faculty residents and post-doctoral fellows in the participating departments and divisions in the School of Medicine (SOM). The proposed program will be directly integrated with existing, more advanced training programs, including MS and PhD degree granting programs in clinical investigation, through the Graduate Training in Program in Clinical Investigation, a joint program of SOM and School of Public Health (SPH), as well as opportunities in basic science, engineering, and SPH programs. The overall goals of the proposed program are:
Aim 1. To provide 1-2 years of intensive research training to radiology trainees to develop into clinician scientists pursuing careers in imaging research.
Aim 2. To provide 1-2 years of intensive research training to trainees in other specialties to pursue research careers utilizing imaging methodologies in their future research careers. By starting early in their careers, the physician trainees will continue to pursue careers in preclinical/clinical investigations incorporating imaging technologies. The success of our approach is confirmed by the fact that 76% of our prior trainees over the past decade continue in research careers. The ultimate outcome will be increased numbers of physicians who will carry out a research career integrated with both basic and applied imaging approaches. During the T32 training years, the trainees will work closely with carefully assigned mentors from radiology and their home department (if outside radiology) and laboratories, with faculty drawn from not only radiology, but also over 11 associated departments and divisions in the SOM, plus biomedical and electrical engineering, computer sciences, informatics, psychology, and SPH. Evaluation will consist of formal progress reports, mock grant preparation and review, publications, and required national presentations, including biannual T32 meetings in Bethesda. The long-term goal is to attract physicians into an academic career employing imaging research as a major component of their future research.

Public Health Relevance

This is a competitive renewal for an additional 5 years of a decade long unique T32 program specializing in 1-2 years of research training in imaging for resident and fellow physicians from Radiology and several departments. The long term goal is to develop the next generation of Physician imaging scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB006351-12
Application #
9734091
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Erim, Zeynep
Project Start
2006-09-30
Project End
2023-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
12
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Plyku, Donika; Mena, Esther; Rowe, Steven P et al. (2018) Combined model-based and patient-specific dosimetry for 18F-DCFPyL, a PSMA-targeted PET agent. Eur J Nucl Med Mol Imaging 45:989-998
Zhong, Bin-Yan; Abiola, Godwin; Weiss, Clifford R (2018) Bariatric Arterial Embolization for Obesity: A Review of Early Clinical Evidence. Cardiovasc Intervent Radiol :
Rubin, Leah H; Sacktor, Ned; Creighton, Jason et al. (2018) Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy. AIDS 32:1661-1667
Jha, Abhinav K; Mena, Esther; Caffo, Brian et al. (2017) Practical no-gold-standard evaluation framework for quantitative imaging methods: application to lesion segmentation in positron emission tomography. J Med Imaging (Bellingham) 4:011011
Vairavamurthy, Jenanan; Cheskin, Lawrence J; Kraitchman, Dara L et al. (2017) Current and cutting-edge interventions for the treatment of obese patients. Eur J Radiol 93:134-142
Mena, Esther; Taghipour, Mehdi; Sheikhbahaei, Sara et al. (2017) Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma. Clin Nucl Med 42:e227-e234
Taghipour, Mehdi; Marcus, Charles; Sheikhbahaei, Sara et al. (2017) Clinical Indications and Impact on Management: Fourth and Subsequent Posttherapy Follow-up 18F-FDG PET/CT Scans in Oncology Patients. J Nucl Med 58:737-743
Taghipour, Mehdi; Mena, Esther; Kruse, Matthew J et al. (2017) Post-treatment 18F-FDG-PET/CT versus contrast-enhanced CT in patients with oropharyngeal squamous cell carcinoma: comparative effectiveness study. Nucl Med Commun 38:250-258
Mena, Esther; Sheikhbahaei, Sara; Taghipour, Mehdi et al. (2017) 18F-FDG PET/CT Metabolic Tumor Volume and Intratumoral Heterogeneity in Pancreatic Adenocarcinomas: Impact of Dual-Time Point and Segmentation Methods. Clin Nucl Med 42:e16-e21
Rowe, Steven P; Macura, Katarzyna J; Ciarallo, Anthony et al. (2016) Comparison of Prostate-Specific Membrane Antigen-Based 18F-DCFBC PET/CT to Conventional Imaging Modalities for Detection of Hormone-Naïve and Castration-Resistant Metastatic Prostate Cancer. J Nucl Med 57:46-53

Showing the most recent 10 out of 73 publications