This training program provides a new type of experienced interdisciplinary scientist in the field of nanobiology, combining the tools, ideas and materials of nanoscience with biology to enable new approaches to research problems and develop novel diagnostic and therapeutic strategies. This new training program builds upon a very successful, interdisciplinary training initiative, supported for a limited duration of five years by the NIH Roadmap Initiative. Trainees from this program are uniquely prepared to explore the interplay between current nanoscience applications in high technology and biotechnology and biomedical applications for clinical and research medicine. Just as early molecular biology heralded a new era in both biological sciences and technology, nanobiology is poised to exploit the adventitious interface between nanoscience and biology. The Nanobiology Interdisciplinary Graduate Training Program (NIGTP) takes advantage of the strong history of multi-institutional, multi-disciplinary training efforts in the Keck Center of the Gulf Coast Consortia. This allows seamless organization of trans-institutional training programs. Bringing together six institutions - Baylor College of Medicine, Rice University, University of Houston, the University of Texas Health Science Center at Houston, University of Texas M. D. Anderson Cancer Center, and the University of Texas Medical Branch at Galveston - the NIGTP faculty bring significant expertise in nanobiology. Fifty faculty are included in this program, with over $63M awarded in research funding related to nanobiology and outstanding graduate research opportunities. Trainees will participate in a highly interdisciplinary curriculum to provide deep knowledge and also the connections between the disciplines. Trainees will also be required to have mentors in two different disciplines, with a mini-sabbatical period in the co-mentor's laboratory as an essential part of the multi-disciplinary training experience. Trainees will also participate in weekly seminars and journal club and will present their research at an annual retreat.

Public Health Relevance

The interface between nanotechnology, biology, and medicine is a new frontier for scientific exploration and for the creation of new and improved diagnostic and therapeutic tools to detect, treat, cure, and prevent human diseases. This grant would support an established interdisciplinary graduate training program in nanotechnology for biology and medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB009379-03
Application #
8089482
Study Section
Special Emphasis Panel (ZEB1-OSR-E (J1))
Program Officer
Baird, Richard A
Project Start
2009-07-01
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
3
Fiscal Year
2011
Total Cost
$305,350
Indirect Cost
Name
Rice University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
050299031
City
Houston
State
TX
Country
United States
Zip Code
77005
Olafson, Katy N; Nguyen, Tam Q; Rimer, Jeffrey D et al. (2017) Antimalarials inhibit hematin crystallization by unique drug-surface site interactions. Proc Natl Acad Sci U S A 114:7531-7536
Aghazadeh, Amirali; Lin, Adam Y; Sheikh, Mona A et al. (2016) Universal microbial diagnostics using random DNA probes. Sci Adv 2:e1600025
Figueroa, Elizabeth R; Yan, J Stephen; Chamberlain-Simon, Nicolette K et al. (2016) Systematically probing the bottom-up synthesis of AuPAMAM conjugates for enhanced transfection efficiency. J Nanobiotechnology 14:24
Chen, Allen L; Jackson, Meredith A; Lin, Adam Y et al. (2016) Changes in Optical Properties of Plasmonic Nanoparticles in Cellular Environments are Modulated by Nanoparticle PEGylation and Serum Conditions. Nanoscale Res Lett 11:303
Zhao, Xiaobei; Chen, Xu-Qiao; Han, Eugene et al. (2016) TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A 113:E5655-64
Wijeratne, Sithara S; Martinez, Jerahme R; Grindel, Brian J et al. (2016) Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix. Matrix Biol 50:27-38
Matthews, James R; Payne, Courtney M; Hafner, Jason H (2015) Analysis of Phospholipid Bilayers on Gold Nanorods by Plasmon Resonance Sensing and Surface-Enhanced Raman Scattering. Langmuir 31:9893-900
Almeida, Joao Paulo Mattos; Lin, Adam Yuh; Figueroa, Elizabeth Raquel et al. (2015) In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models. Small 11:1453-1459
Watson, Brendan M; Vo, Tiffany N; Tatara, Alexander M et al. (2015) Biodegradable, phosphate-containing, dual-gelling macromers for cellular delivery in bone tissue engineering. Biomaterials 67:286-96
Frey, Eric W; Li, Jingqiang; Wijeratne, Sithara S et al. (2015) Reconstructing multiple free energy pathways of DNA stretching from single molecule experiments. J Phys Chem B 119:5132-5

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