The number of available organs is severely limited by a shortage of donors. A new field of science, regenerative medicine, has emerged that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. T develop functional tissue requires applying concepts in developmental biology, quantitative science and tissue engineering approaches in a novel way. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and other disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training to postdoctoral fellows at Harvard and MIT. Individuals accepted into the Program are cross-trained in an area of expertise outside of their primary research field. This is a continuation of an ARRA-funded training program, reduced in size. Working at the intersection of engineering and developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program mentoring and a required course. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the one postdoctoral fellow - one mentor - one laboratory approach to a true [dual-mentor model where fellows spend time in the laboratories of two mentors and are able to facilitate active communication across laboratories, institutions and geographic boundaries.] This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 5 years have high quality publications, have moved to academic faculty, international research lab and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.
We present an interdisciplinary postdoctoral training program designed to nurture the development of and provide scientifically rigorous, multidisciplinary research training for future leaders during their early, formative stages. This is accomplished by providing our trainees with research training under dual mentorship, outstanding training in disciplines critical to the application of engineering principles for organ design, and resources o prominent affiliated institutions with cutting-edge basic science, clinical, and translational research programs.
|Li, Matthew; Khong, Danika; Chin, Ling-Yee et al. (2018) Therapeutic Delivery Specifications Identified Through Compartmental Analysis of a Mesenchymal Stromal Cell-Immune Reaction. Sci Rep 8:6816|
|Zimmerman, John F; Tian, Bozhi (2018) Nongenetic Optical Methods for Measuring and Modulating Neuronal Response. ACS Nano 12:4086-4095|
|Kaushik, Gaurav; Leijten, Jeroen; Khademhosseini, Ali (2017) Concise Review: Organ Engineering: Design, Technology, and Integration. Stem Cells 35:51-60|
|Sadeghi, Amir Hossein; Shin, Su Ryon; Deddens, Janine C et al. (2017) Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling. Adv Healthc Mater 6:|
|Polacheck, William J; Kutys, Matthew L; Yang, Jinling et al. (2017) A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature 552:258-262|
|Polacheck, William J; Chen, Christopher S (2016) Measuring cell-generated forces: a guide to the available tools. Nat Methods 13:415-23|
|Hinson, John T; Chopra, Anant; Nafissi, Navid et al. (2015) HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science 349:982-6|