The NIEHS Training Program in Environmental Health Sciences has supported 62 former pre-doctoral and 24 former postdoctoral trainees since 1996. Forty-three former pre-doctoral and 20 former postdoctoral trainees are in career positions in the private sector/industry, government or academia. Combined, current and former trainees have published over 300 peer-reviewed papers and book chapters. Consistent with the new NIEHS T32 guidelines, this Training Program has been restructured and has a new mission, goals and research foci. The mission of the Training Program is to actively prepare research scientists to become future leaders of individual and interdisciplinary research projects that seek to understand the role that environmental exposures play in the etiology and exacerbation of human disease at the individual and population level. The mission will be accomplished by providing support for pre- and postdoctoral trainees involved in research on the role of exposures to environmental agents (e.g. various chemicals, metals, particulates, fungal or bacterial-derived toxicants) as causative agents or co-factors in human disease. Trainee research will focus on one or more of the following: Mechanisms of exposures to environmental agents that alter biological processes that contribute to disease pathobiology;Development of biomarkers of disease pathobiology (e.g., biomarkers of response, effect, and susceptibility to toxic agents);Development of intervention strategies based upon mechanistic studies to prevent adverse effects that contribute to disease caused by exposure to environmental agents;and Epidemiology to identify population-based associations of environmental agents with disease. The research of the training faculty is focused on investigations on the contributions of environmental agents to the following diseases: cancer, immune system diseases, neurological diseases, pulmonary and cardiovascular diseases, and reproductive and developmental diseases. The research being conducted by the faculty together with pre-doctoral and postdoctoral trainees addresses one or more of the following: 1) mechanisms of disease pathobiology;2) development of biomarkers of the pathobiology (e.g. biomarkers of response, effect, susceptibility);3) development of prevention/intervention strategies;and 4) disease epidemiology. BACKGROUND This Training Program is in its twenty-fifth year. Over the years, this Training Program has evolved and continues to evolve in order to respond to the new NIEHS guidelines. The program is both interdisciplinary and interdepartmental. The academic departments that are involved in the current application are the Departments of Environmental Health Sciences, Biochemistry and Molecular Biology, and Epidemiology. As a part of the response to the new NIEHS guidelines, a new mission statement and new goals have been developed. Faculty members whose research focus does not encompass the new mission are no longer members so that the number of faculty members that are involved in the training faculty has been reduced to 26. Additionally, there is a shift in the number of requested support for pre-doctoral and postdoctoral positions. The move is from 20 pre-doctoral positions to 14 and from 3 postdoctoral positions to 7.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Public Health & Prev Medicine
Schools of Public Health
United States
Zip Code
Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129
Gour, Naina; Lajoie, Stephane; Smole, Ursula et al. (2018) Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases. Sci Immunol 3:
Balakrishnan, Poojitha; Jones, Miranda R; Vaidya, Dhananjay et al. (2018) Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Int J Environ Res Public Health 15:
Spratlen, Miranda J; Grau-Perez, Maria; Best, Lyle G et al. (2018) The Association of Arsenic Exposure and Arsenic Metabolism with the Metabolic Syndrome and its Individual Components: Prospective Evidence from the Strong Heart Family Study. Am J Epidemiol :
Davis, Meghan F; Pisanic, Nora; Rhodes, Sarah M et al. (2018) Occurrence of Staphylococcus aureus in swine and swine workplace environments on industrial and antibiotic-free hog operations in North Carolina, USA: A One Health pilot study. Environ Res 163:88-96
Luechtefeld, Thomas; Rowlands, Craig; Hartung, Thomas (2018) Big-data and machine learning to revamp computational toxicology and its use in risk assessment. Toxicol Res (Camb) 7:732-744
Gour, Naina; Smole, Ursula; Yong, Hwan-Mee et al. (2018) C3a is required for ILC2 function in allergic airway inflammation. Mucosal Immunol 11:1653-1662
Poulsen, Melissa N; Pollak, Jonathan; Sills, Deborah L et al. (2018) Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. Int J Hyg Environ Health 221:323-333
Gour, Naina; Sudini, Kuladeep; Khalil, Syed Muaz et al. (2018) Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash. Environ Res 161:304-313
Spratlen, Miranda J; Grau-Perez, Maria; Umans, Jason G et al. (2018) Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740

Showing the most recent 10 out of 230 publications