This application is the second re-submission of the University of Pittsburgh's graduate training program in computational toxicology. This program is a joint effort of the Department of Environmental and Occupational Health (DEOH) within the Graduate School of Public Health and the Department of Computer Sciences within the School of Arts and Sciences. The program is administratively housed within the DEOH. The program seeks to offer pre- and postdoctoral training that will allow graduates to apply computational techniques to model and develop: (1) toxicological dose-response relationships, (2) three-dimensional ligand-receptor interactions, (3) expert systems to generate hypotheses regarding toxicological phenomena, and (4) mechanistically informative structure activity relationship (SAR) models. SAR-based approaches are a unifying theme of this program. Since the last re- submission physiologically based pharmacokinetic (PBPK) model development has been dropped as a modeling area. The program is highly interdisciplinary in both the makeup of the faculty and the required curriculum. Dr. Herbert S. Rosenkranz, the Program Director, is chair of DEOH and the co-Director, Dr. Bruce Buchanan is a Professor in Department of Computer Sciences. The involved faculty members have a broad range of primary affiliations including the DEOH, Department of Computer Sciences, Biostatistics, Pittsburgh Supercomputer Center, Carnegie Mellon University, and private industry. Two additional faculty have been added since the last re-submission, Dr. Mazdumar (Biostatistics) and Dr. Cunningham (DEOH). The predoctoral curriculum is designed to be integrated and interdisciplinary. Required courses span the disciplines of toxicology (6 credits), exposure assessment (6 credits), biostatistics (9 credits), epidemiology (2 credits), and computational sciences (15 credits). Six credit hours of electives from among these disciplines are required as is participation in the Survival Skills and Ethics Program. Total course credits required are 46 plus 30 research credits for a total of 76 credits. Attendance at departmental seminars and journal club is also required.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007318-03
Application #
6498263
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
3
Fiscal Year
2002
Total Cost
$84,199
Indirect Cost
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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