The purpose of the proposed program is to provide pre- and post-doctoral training in mechanistically based quantitative toxicology to quantify individuals for research and teaching positions in universities and medical institutions, or research positions in national laboratories and other governmental agencies. Because of the uniqueness of the proposed training program in quantitative toxicology and its potential application in science-based risk assessment, it is conceivable that our trainees will be sought after by industry as well. The major research emphasis is toxicologic interactions of chemicals and physical agents. The endpoints to be studied are mutagenesis and carcinogenesis. Mechanistic studies will be integrated with physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling and biologically based dose response (BBDR) modeling. Predoctoral trainees will enter the program with bachelor or masters' degree in biology, biochemistry, or chemistry. Exceptional candidates in physics, mathematics, or engineering interested in pursuing an advanced training in toxicology will be considered as well. They will be selected on the basis of their personal goals, past academic performance, scores on the Graduate Record Examination, and letters of recommendation. In those exceptional cases, where deficiencies in biology or other disciplines exist, remedial course work will be completed in the first year. Candidates considered for post-doctoral positions will include individuals with Ph.D., M.D., D.V.M. degrees. They must demonstrate meritorious academic work, have letters of reference attesting to their motivation, competence, and past research performance, and aspire to a research and/or teaching career related to toxicology. Candidates who are presently in a post-doctoral position with exceptional molecular biology skills and knowledge may be considered for re-training in quantitative toxicology to broadening their skills. This application requests support for 10 predoctoral and 5 post-doctoral traineeships.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007321-04
Application #
6498265
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1999-07-01
Project End
2004-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
4
Fiscal Year
2002
Total Cost
$276,587
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Public Health & Prev Medicine
Type
Schools of Veterinary Medicine
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
Lohitnavy, Manupat; Lu, Yasong; Lohitnavy, Ornrat et al. (2008) A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling. Toxicol Sci 104:27-39
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Reddy, Micaela B; Looney, Richard John; Utell, Mark J et al. (2007) Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)). Toxicol Sci 99:422-31
Lu, Yasong; Lohitnavy, Manupat; Reddy, Micaela B et al. (2006) An updated physiologically based pharmacokinetic model for hexachlorobenzene: incorporation of pathophysiological states following partial hepatectomy and hexachlorobenzene treatment. Toxicol Sci 91:29-41
Mayeno, Arthur N; Yang, Raymond S H; Reisfeld, Brad (2005) Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures. Environ Sci Technol 39:5363-71
Dennison, James E; Andersen, Melvin E; Yang, Raymond S H (2005) Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systems. Inhal Toxicol 17:539-48

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