A recent trend in the health sciences is the increasing use of not only genomic but also other ?omics data. Scientists who can effectively design studies to collect these data, develop computational and statistical methods to analyze these data, and/or deploy prevention or diagnostic programs that utilize these data will be playing leadership roles in tomorrow's research world. The field of environmental health is rapidly evolving in response to these new technologies. No longer simply concerned with describing exposure- response relations in human populations (epidemiology) and model organisms (toxicology), new avenues for research include advances in exposure science (mobile sensing technologies, biomonitoring, etc.), in mechanisms of environmental diseases (integrative genomics including gene-environment interactions), and novel ways of integrating epidemiologic, genetic and toxicological approaches. Training the next generation of scientists in this field will require a highly multi-disciplinary approach. This is a renewal of the University of Southern California T32 training grant in Environmental Genomics, aimed at providing multidisciplinary education and research training for five pre-doctoral and four postdoctoral trainees. For Ph.D. candidates, the Program involves rigorous course work within our Ph.D. degree programs in Biostatistics and Epidemiology (with tracks, among others, in statistical genetics, environmental statistics, genetic and molecular epidemiology, and environmental epidemiology), with a set of core knowledge aimed at bridging these various fields. At the postdoctoral level, the emphasis is on research experience within one of the leading research departments in the country. A large interdisciplinary team of faculty with a tradition of individual hands-on research mentorship and extensive portfolios of research grant support in environmental epidemiology, genetics, biostatistics, and bioinformatics are available to trainees.

Public Health Relevance

The next generation of investigators in environmental health will need broad multidisciplinary training. The investigators aim to provide pre- and postdoctoral trainees with training in environmental, genetic, and molecular epidemiology, biostatistics, and bioinformatics to become leaders in research on the complex pathways that lead from environmental exposures to disease in human populations.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
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Environmental Health Sciences Review Committee (EHS)
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Shreffler, Carol A
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University of Southern California
Public Health & Prev Medicine
Schools of Medicine
Los Angeles
United States
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Alderete, T L; Song, A Y; Bastain, T et al. (2018) Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight. Pediatr Obes 13:348-356
Kerin, Tara; Volk, Heather; Li, Weiyan et al. (2018) Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord 48:137-150
Kim, Jeniffer S; Alderete, Tanya L; Chen, Zhanghua et al. (2018) Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index. Environ Health 17:64
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296
Moss, Lilit C; Gauderman, William J; Lewinger, Juan Pablo et al. (2018) Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol :
Farzan, Shohreh F; Howe, Caitlin G; Zens, Michael S et al. (2017) Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study. Environ Health Perspect 125:127002
Chen, Connie; Gribble, Matthew O; Bartroff, Jay et al. (2017) The Sequential Probability Ratio Test: An efficient alternative to exact binomial testing for Clean Water Act 303(d) evaluation. J Environ Manage 192:89-93
Alderete, Tanya L; Habre, Rima; Toledo-Corral, Claudia M et al. (2017) Longitudinal Associations Between Ambient Air Pollution With Insulin Sensitivity, ?-Cell Function, and Adiposity in Los Angeles Latino Children. Diabetes 66:1789-1796
Howe, Caitlin G; Li, Zhigang; Zens, Michael S et al. (2017) Dietary B Vitamin Intake Is Associated with Lower Urinary Monomethyl Arsenic and Oxidative Stress Marker 15-F2t-Isoprostane among New Hampshire Adults. J Nutr 147:2289-2296

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